UniProt P30542
Adenosine receptor A1,Soluble cytochrome b562,Adenosine receptor A1 (P30542)
Adenosine receptor A1,Soluble cytochrome b562,Adenosine receptor A1 (UniProt P30542): 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 26 pockets. Binding sites, druggability and experiment against…
- UniProt
- P30542
- Protein
- Adenosine receptor A1,Soluble cytochrome b562,Adenosine receptor A1
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 26 · 4 records with a druggable one
Structures
10 records of P30542 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5N2S | Crystal structure of stabilized A1 receptor in complex with PSB36 at 3.3A resolution | x-ray diffraction | A | 8K8, SO4 | 6 (best 0.77) |
| 5N2S | Crystal structure of stabilized A1 receptor in complex with PSB36 at 3.3A resolution | x-ray diffraction | A | 8K8, SO4 | — |
| 5UEN | Crystal structure of the human adenosine A1 receptor A1AR-bRIL in complex with the covalent… | x-ray diffraction | A, B | DU1, OLA | 10 (best 0.76) |
| 5UEN | Crystal structure of the human adenosine A1 receptor A1AR-bril in complex with the covalent… | x-ray diffraction | A, B | DU1, OLA | — |
| 6D9H | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | R | ADN | — |
| 7LD3 | Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous… | electron microscopy | R | ADN, XTD | 5 (best 0.74) |
| 7LD3 | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | R | ADN, XTD | — |
| 7LD4 | Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous… | electron microscopy | R | ADN | 5 (best 0.79) |
| 7LD4 | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | R | ADN | — |
| P30542 | AlphaFold monomer V2.0 prediction for adenosine receptor A1 (P30542) | predicted | A | — | — |
Ligands
- ADN · Adenosine · in 5 records
- 8K8 · 1-butyl-3-(3-oxidanylpropyl)-8-[(1~{R},5~{S})-3-tricyclo[3.3.1.0^{3,7}]nonanyl]-7~{H}-purine-2,6-dione · in 2 records
- DU1 · 4-{[3-(8-cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-3H-purin-3-yl)propyl]carbamoyl}benzene-1-sulfonyl fluoride · in 2 records
- OLA · Oleic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- XTD · {2-amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone · in 2 records
Experiment against prediction
- 5UEN chain A against the predicted model P30542: TM-score 0.80, RMSD 0.90 Å
- 5UEN chain A against the predicted model P30542: TM-score 0.80, RMSD 0.90 Å
- 5UEN chain B against the predicted model P30542: TM-score 0.79, RMSD 0.52 Å
- 5UEN chain B against the predicted model P30542: TM-score 0.79, RMSD 0.52 Å
- 7LD4 chain R against the predicted model P30542: TM-score 0.92, RMSD 2.29 Å
- 7LD4 chain R against the predicted model P30542: TM-score 0.92, RMSD 2.29 Å
- 7LD3 chain R against the predicted model P30542: TM-score 0.92, RMSD 2.28 Å
- 7LD3 chain R against the predicted model P30542: TM-score 0.92, RMSD 2.28 Å
- 6D9H chain R against the predicted model P30542: TM-score 0.92, RMSD 2.27 Å
- 5N2S chain A against the predicted model P30542: TM-score 0.72, RMSD 1.78 Å
Elsewhere
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