UniProt P29994
Inositol 1,4,5-trisphosphate receptor type 1 (P29994)
Inositol 1,4,5-trisphosphate receptor type 1 (UniProt P29994): 13 experimental structures on GenesisL1, 6 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P29994
- Protein
- Inositol 1,4,5-trisphosphate receptor type 1
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 40 · 2 records with a druggable one
Structures
13 records of P29994 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JAV | Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | electron microscopy | A, B, C, D | — | — |
| 3JAV | Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | electron microscopy | A, B, C, D | — | — |
| 3T8S | Apo and INSP3-bound crystal structures of the ligand-binding domain of an INSP3 receptor | x-ray diffraction | — | — | |
| 3UJ0 | Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form. | x-ray diffraction | A, B | — | — |
| 3UJ0 | Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form. | x-ray diffraction | A, B | — | — |
| 3UJ4 | Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor | x-ray diffraction | A, B | — | — |
| 3UJ4 | Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor | x-ray diffraction | A, B | — | — |
| 6MU1 | Structure of full-length IP3R1 channel bound with adenophostin a | electron microscopy | A, C, B, D | JYP | — |
| 6MU2 | Structure of full-length IP3R1 channel in the apo-state | electron microscopy | B, A, D, C | — | — |
| 7LHE | Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state | electron microscopy | A, D, C, B | PLX, ZN | — |
| 7LHF | Structure of full-length IP3R1 channel solubilized in lnmg & lipid in the apo-state | electron microscopy | A, D, B, C | PLX, ZN | — |
| 8EAQ | Structure of the full-length IP3R1 channel determined at high Ca2+ | electron microscopy | A, B, C, D | ZN, CA, PLX | 20 (best 0.83) |
| 8EAR | Structure of the full-length IP3R1 channel determined in the presence of Calcium/IP3/ATP | electron microscopy | A, B, C, D | ZN, ATP, I3P, CA, PLX | 20 (best 0.84) |
Ligands
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 4 records
- ZN · Zinc ion · in 4 records
- CA · Calcium ion · in 2 records
- ATP · Adenosine-5'-triphosphate · in 1 record
- I3P · D-myo-inositol-1,4,5-triphosphate · in 1 record
- JYP · Adenophostin A · in 1 record
Elsewhere
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