MolNFT v1 · #157279 · protein
Structure of full-length IP3R1 channel in the apo-state
6MU2 · Inositol 1,4,5-trisphosphate receptor type 1: “Structure of full-length IP3R1 channel in the apo-state”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #157279 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6MU2
- Type
- protein
- Length
- 8,680 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inositol 1,4,5-trisphosphate receptor type 1
- UniProt
- P29994
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 55% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, D, C | Inositol 1,4,5-trisphosphate receptor type 1 | protein | 2170 | 55% helix, 4% strand | P29994 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 775 | 0.82 | 0.84 | 63 | empty |
| 2 | 149 | 0.82 | 0.97 | 41 | empty |
| 3 | 1148 | 0.82 | 0.83 | 89 | empty |
| 4 | 143 | 0.81 | 0.97 | 39 | empty |
| 5 | 577 | 0.81 | 0.86 | 94 | empty |
Interfaces
6 interfaces between chains.
- A–D · 3708 Ų buried · 23 hydrogen bonds · protein-protein
- B–A · 3692 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 3690 Ų buried · 24 hydrogen bonds · protein-protein
- D–C · 3654 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 172 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6MU2 · Structure of full-length IP3R1 channel in the Apo-state · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29994
- Elsewhere: RCSB PDB 6MU2 · PDBe 6MU2 · UniProt P29994
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