UniProt P29808
Aminoglycoside N(3)-acetyltransferase III (P29808)
Aminoglycoside N(3)-acetyltransferase III (UniProt P29808), EC 2.3.1.81: 7 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P29808
- Protein
- Aminoglycoside N(3)-acetyltransferase III
- EC
- 2.3.1.81
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 40 · 4 records with a druggable one
Structures
8 records of P29808 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MQK | AAC(3)-IIIa in complex with CoA and sisomicin | x-ray diffraction | A, B, C, D | SIS, COA | 12 (best 0.55) |
| 7MQK | AAC(3)-iiia in complex with CoA and sisomicin | x-ray diffraction | A, B, C, D | SIS, COA | — |
| 7MQL | AAC(3)-IIIa in complex with CoA and neomycin | x-ray diffraction | A, B, C, D | COA, RIO | 13 (best 0.52) |
| 7MQL | AAC(3)-iiia in complex with CoA and neomycin | x-ray diffraction | A, B, C, D | COA, RIO | — |
| 7MQM | AAC(3)-IIIa in complex with CoA and gentamicin | x-ray diffraction | A, B, C, D | COA, 51G | 13 (best 0.53) |
| 7MQM | AAC(3)-iiia in complex with CoA and gentamicin | x-ray diffraction | A, B, C, D | COA, 51G | — |
| 7Q1X | Acetyltrasferase(3) type IIIa in complex with neomycin B | x-ray diffraction | A, B | NMY, CL | 2 (best 0.75) |
| P29808 | AlphaFold monomer V2.0 prediction for aminoglycoside N(3)-acetyltransferase III (P29808) | predicted | A | — | — |
Ligands
- COA · Coenzyme A · in 6 records
- 51G · gentamicin C1 · in 2 records
- RIO · Ribostamycin · in 2 records
- SIS · (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside · in 2 records
- CL · Chloride ion · in 1 record
- NMY · Neomycin · in 1 record
Experiment against prediction
- 7MQM chain D against the predicted model P29808: TM-score 0.99, RMSD 0.72 Å
- 7MQM chain D against the predicted model P29808: TM-score 0.99, RMSD 0.72 Å
- 7MQL chain D against the predicted model P29808: TM-score 0.99, RMSD 0.72 Å
- 7MQL chain D against the predicted model P29808: TM-score 0.99, RMSD 0.72 Å
- 7MQL chain C against the predicted model P29808: TM-score 0.99, RMSD 0.74 Å
- 7MQL chain C against the predicted model P29808: TM-score 0.99, RMSD 0.74 Å
- 7MQM chain C against the predicted model P29808: TM-score 0.99, RMSD 0.74 Å
- 7MQM chain C against the predicted model P29808: TM-score 0.99, RMSD 0.74 Å
- 7MQK chain C against the predicted model P29808: TM-score 0.99, RMSD 0.75 Å
- 7MQK chain C against the predicted model P29808: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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