Ligand · SIS
SIS · (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
SIS, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (C19 H37 N5 O7, 447.5 g/mol), in the MolNFT structures on…
- Component
- SIS
- Formula
- C19 H37 N5 O7
- Class
- ligand
- Structures
- 17
- PDB entries
- 14
Binding sites
SIS in 17 structures; the first of them:
- 6NP2 · AAC-VIa bound to Sisomicin · SIS A301 · binds PHE77, SER79, TRP80, SER83, TYR85, GLU86, TYR113, PHE116 and 10 more
- 7CSI · Aminoglycoside 2'-N-acetyltransferase from Mycolicibacterium smegmatis-Complex with… · SIS A301 · binds PHE42, ASP54, PHE55, ASP59, GLU106, ALA107, SER141, ALA142 and 9 more
- 7DUJ · Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and… · SIS A1833 · binds 5MC1404, G1405, U1406, 5MC1407, A1408, C1409, G1491, A1492 and 3 more
- 5U08 · Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured… · SIS A201 · binds PHE35, ASP91, ASP128, HIS151, TYR153, TYR81, GLU121, GLU122 and 2 more
- 6BBZ · Room temperature NEUTRON/X-ray structure of sisomicin bound aac-via · SIS A301 · binds SER79, TYR85, GLU86, TYR113, PHE116, ASP136, TYR159, ASP183 and 3 more
- 6BC3 · Cryo X-ray structure of sisomicin bound aac-via · SIS A302 · binds SER79, TYR85, GLU86, TYR113, PHE116, ASP136, TYR159, ASP183 and 4 more
- 6BC7 · Cryo X-ray structure of sisomicin bound aac-via · SIS A301 · binds PHE77, SER79, TRP80, TYR85, TYR113, PHE116, ASP136, TYR159 and 5 more
- 6CAP · Crystal structure of 30S ribosomal subunit from thermus thermophilus in complex with… · SIS A1792 · binds 5MC1404, G1405, U1406, 5MC1407, A1408, C1409, G1491, A1493 and 2 more
- 6CAR · Serial femtosecond X-ray crystal structure of 30S ribosomal subunit from thermus… · SIS A1809 · binds 5MC1404, G1405, U1406, 5MC1407, A1408, G1491, A1493, G1494 and 1 more
- 6MB4 · Binary (sisomicin) structure of aac-iiib · SIS B301 · binds TYR65, ASP67, GLU73, GLY124, TYR147, ASP171, THR172, HIS177 and 5 more
- 6MN2 · Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme… · SIS A302 · binds TYR62, ASP64, TRP65, ASP69, GLY115, TYR138, ASP162, THR163 and 3 more
- 6NP2 · Aac-via bound to sisomicin · SIS A301 · binds SER79, TYR85, GLU86, TYR113, PHE116, ASP136, TYR159, ASP183 and 4 more
- 7CSI · Aminoglycoside 2'-N-acetyltransferase from mycolicibacterium smegmatis-complex with… · SIS A301 · binds PHE42, ASP54, PHE55, ASP59, SER141, ALA142, SER143, ASP144 and 4 more
- 7DUJ · Crystal structure of the thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and… · SIS A1833 · binds 5MC1404, G1405, U1406, 5MC1407, A1408, C1409, G1491, A1492 and 3 more
- 7DUK · Crystal structure of the thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and… · SIS A1835 · binds 5MC1404, G1405, U1406, 5MC1407, A1408, C1409, G1491, A1493 and 2 more
- 7DUL · Crystal structure of the thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and… · SIS A1835 · binds 5MC1404, G1405, U1406, 5MC1407, A1408, C1409, G1491, A1493 and 2 more
- 7MQK · AAC(3)-iiia in complex with CoA and sisomicin · SIS A501 · binds TYR64, ILE70, ASP72, GLU123, TYR146, ASP170, HIS176, THR212 and 2 more
Residues it binds most
ASP 20, TYR 16, GLU 17, SER 11, PHE 17, G 6, A 6, 5MC 6, U 6, HIS 11 (residue and the binding sites it lines).
Found with
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