UniProt P27472
Glycogen [starch] synthase isoform 2 (P27472)
Glycogen [starch] synthase isoform 2 (UniProt P27472), EC 2.4.1.11: 28 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 150 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P27472
- Protein
- Glycogen [starch] synthase isoform 2
- EC
- 2.4.1.11
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 150 · 8 records with a druggable one
Structures
29 records of P27472 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NAZ | Basal state form of Yeast Glycogen Synthase | x-ray diffraction | A, B, C, D | — | — |
| 3NAZ | Basal state form of yeast glycogen synthase | x-ray diffraction | A, B, C, D | — | — |
| 3NB0 | Glucose-6-Phosphate activated form of Yeast Glycogen Synthase | x-ray diffraction | A, B, C, D | — | — |
| 3NB0 | Glucose-6-phosphate activated form of yeast glycogen synthase | x-ray diffraction | A, B, C, D | — | — |
| 3NCH | Yeast Glycogen Synthase (Gsy2p) Basal State Conformation | x-ray diffraction | A, B, C, D | — | — |
| 3NCH | Yeast glycogen synthase (GSY2P) basal state conformation | x-ray diffraction | A, B, C, D | — | — |
| 3O3C | Glycogen synthase basal state UDP complex | x-ray diffraction | A, B, C, D | — | — |
| 3O3C | Glycogen synthase basal state udp complex | x-ray diffraction | A, B, C, D | — | — |
| 3RSZ | Maltodextran bound basal state conformation of yeast glycogen synthase isoform 2 | x-ray diffraction | A, B, C, D | — | — |
| 3RSZ | Maltodextran bound basal state conformation of yeast glycogen synthase isoform 2 | x-ray diffraction | A, B, C, D | — | — |
| 3RT1 | Maltodextarn bound activated state form of yeast glycogen synthase isoform 2 | x-ray diffraction | A, B, C, D | — | — |
| 3RT1 | Maltodextarn bound activated state form of yeast glycogen synthase isoform 2 | x-ray diffraction | A, B, C, D | — | — |
| 5SUK | G6P bound activated state of yeast glycogen synthase 2 | x-ray diffraction | A, B, C, D | G6P | 20 (best 0.75) |
| 5SUK | G6P bound activated state of yeast glycogen synthase 2 | x-ray diffraction | A, B, C, D | G6P | — |
| 5SUL | Inhibited state structure of yGsy2p | x-ray diffraction | A, B | UDP, U5P | 10 (best 0.71) |
| 5SUL | Inhibited state structure of YGSY2P | x-ray diffraction | A, B | UDP, U5P | — |
| 5UW0 | Activated state yGsy2p in complex with UDP-2-fluoro-2-deoxy-glucose | x-ray diffraction | A, B, C, D | UDP, G6P, U2F | 20 (best 0.78) |
| 5UW0 | Activated state YGSY2P in complex with udp-2-fluoro-2-deoxy-glucose | x-ray diffraction | A, B, C, D | UDP, G6P, U2F | — |
| 5UW1 | Activated state yGsy2p in complex with UDP-galactose | x-ray diffraction | A, B, C, D | GDU, G6P | 20 (best 0.74) |
| 5UW1 | Activated state YGSY2P in complex with udp-galactose | x-ray diffraction | A, B, C, D | GDU, G6P | — |
| 5UW4 | Activated yeast Glycogen Synthase in complex with UDP glucosamine | x-ray diffraction | C, B, A, D | GCS, UDP, G6P | 20 (best 0.80) |
| 5UW4 | Activated yeast glycogen synthase in complex with udp glucosamine | x-ray diffraction | C, B, A, D | GCS, UDP, G6P | — |
| 5UX7 | Activated state yeast Glycogen Synthase in complex with UDP-xylose | x-ray diffraction | A, B, C, D | UDP, G6P, UDX | 20 (best 0.77) |
| 5UX7 | Activated state yeast glycogen synthase in complex with udp-xylose | x-ray diffraction | A, B, C, D | UDP, G6P, UDX | — |
| 5VNC | Glycogen synthase in complex with UDP and glucosamine | x-ray diffraction | A, B, C, D | UDP, G6P, GCS | 20 (best 0.77) |
| 5VNC | Glycogen synthase in complex with udp and glucosamine | x-ray diffraction | A, B, C, D | UDP, G6P, GCS | — |
| 6U77 | yGsy2p in complex with small molecule | x-ray diffraction | A, B, C, D | G6P, VMC | 20 (best 0.71) |
| 6U77 | YGSY2P in complex with small molecule | x-ray diffraction | A, B, C, D | G6P, VMC | — |
| P27472 | AlphaFold monomer V2.0 prediction for glycogen [starch] synthase isoform 2 (P27472) | predicted | A | — | — |
Ligands
- G6P · 6-O-phosphono-alpha-D-glucopyranose · in 14 records
- UDP · Uridine-5'-diphosphate · in 10 records
- GCS · 2-amino-2-deoxy-beta-D-glucopyranose · in 4 records
- GDU · Galactose-uridine-5'-diphosphate · in 2 records
- U2F · Uridine-5'-diphosphate-2-deoxy-2-fluoro-alpha-D-glucose · in 2 records
- U5P · Uridine-5'-monophosphate · in 2 records
- UDX · Uridine-5'-diphosphate-xylopyranose · in 2 records
- VMC · 2-methoxy-4-(1-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-4-phenyl-1H-imidazol-5-yl)phenol · in 2 records
Experiment against prediction
- 5UW1 chain A against the predicted model P27472: TM-score 1.00, RMSD 0.49 Å
- 5UW1 chain A against the predicted model P27472: TM-score 1.00, RMSD 0.49 Å
- 5UW0 chain A against the predicted model P27472: TM-score 1.00, RMSD 0.52 Å
- 5UW0 chain A against the predicted model P27472: TM-score 1.00, RMSD 0.52 Å
- 5VNC chain A against the predicted model P27472: TM-score 1.00, RMSD 0.54 Å
- 5VNC chain A against the predicted model P27472: TM-score 1.00, RMSD 0.54 Å
- 5UX7 chain A against the predicted model P27472: TM-score 1.00, RMSD 0.55 Å
- 5UX7 chain A against the predicted model P27472: TM-score 1.00, RMSD 0.55 Å
- 5SUK chain C against the predicted model P27472: TM-score 1.00, RMSD 0.58 Å
- 5SUK chain C against the predicted model P27472: TM-score 1.00, RMSD 0.58 Å
Elsewhere
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