UniProt P26049
Gamma-aminobutyric acid receptor subunit alpha-3 (P26049)
Gamma-aminobutyric acid receptor subunit alpha-3 (UniProt P26049): 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P26049
- Protein
- Gamma-aminobutyric acid receptor subunit alpha-3
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 21 · 3 records with a druggable one
Structures
5 records of P26049 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8G4X | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | C | NAG, FUC, ABU, PIO, Y4B | 9 (best 0.82) |
| 8G5F | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | A | NAG, FUC, PIO, Y4B, ABU | 6 (best 0.83) |
| 8G5G | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | C | NAG, FUC, ABU, R5R, PIO | — |
| 8G5H | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | A | NAG, FUC, ABU, PIO, Y4B | 6 (best 0.83) |
| P26049 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-3 (P26049) | predicted | A | — | — |
Ligands
- ABU · Gamma-amino-butanoic acid · in 4 records
- FUC · alpha-L-fucopyranose · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 4 records
- Y4B · allopregnanolone · in 3 records
- R5R · Zolpidem · in 1 record
Experiment against prediction
- 8G5H chain A against the predicted model P26049: TM-score 0.95, RMSD 1.41 Å
- 8G5F chain A against the predicted model P26049: TM-score 0.94, RMSD 1.46 Å
- 8G4X chain C against the predicted model P26049: TM-score 0.92, RMSD 1.79 Å
- 8G5G chain C against the predicted model P26049: TM-score 0.91, RMSD 1.98 Å
Elsewhere
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