UniProt P26012
Integrin beta-8 (P26012)
Integrin beta-8 (UniProt P26012): 15 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 72 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P26012
- Protein
- Integrin beta-8
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 72 · 8 records with a druggable one
Structures
16 records of P26012 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DJP | Integrin alpha-V beta-8 in complex with the fabs 8B8 and 68 | electron microscopy | B | NAG | — |
| 6OM1 | Crystal structure of an atypical integrin | x-ray diffraction | B, D, F, H | NAG, MG, CA | 16 (best 0.85) |
| 6OM1 | Crystal structure of an atypical integrin | x-ray diffraction | B, D, F, H | NAG, MG, CA | — |
| 6OM2 | Crystal structure of atypical integrin alphav BETA8 with protgf-BETA1 ligand peptide | x-ray diffraction | B, D | NAG, MG, CA | — |
| 6UJA | Integrin alpha-v beta-8 in complex with pro-TGF-beta1 | electron microscopy | B | NAG, CA, MG | 8 (best 0.79) |
| 6UJA | Integrin alpha-V beta-8 in complex with pro-TGF-BETA1 | electron microscopy | B | NAG, CA, MG | — |
| 6UJB | Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 | electron microscopy | B | NAG, CA, MG | 7 (best 0.79) |
| 6UJB | Integrin alpha-V beta-8 in complex with the fabs C6D4 and 11D12V2 | electron microscopy | B | NAG, CA, MG | — |
| 6UJC | Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2 | electron microscopy | B | NAG, CA, MG | 11 (best 0.77) |
| 6UJC | Integrin alpha-V beta-8 in complex with the fabs C6-RGD3 and 11D12V2 | electron microscopy | B | NAG, CA, MG | — |
| 7Y1T | Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2 | electron microscopy | B | NAG, CA, MN | 10 (best 0.81) |
| 7Y1T | Complex of integrin ALPHAV/BETA8 and L-TGF-BETA1 at a ratio of 1:2 | electron microscopy | B | NAG, CA, MN | — |
| 8TCF | Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf | electron microscopy | B | NAG, CA, MG | 7 (best 0.81) |
| 8VS6 | L-TGF-b3/avb8 | electron microscopy | B | NAG, CA, MG | 6 (best 0.79) |
| 8VSD | avb8/L-TGF-b1/GARP | electron microscopy | B | NAG, CA, MG | 7 (best 0.79) |
| P26012 | AlphaFold monomer V2.0 prediction for integrin beta-8 (P26012) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8VS6 chain B against the predicted model P26012: TM-score 0.98, RMSD 0.95 Å
- 6OM1 chain F against the predicted model P26012: TM-score 0.98, RMSD 0.91 Å
- 6OM1 chain F against the predicted model P26012: TM-score 0.98, RMSD 0.91 Å
- 6UJA chain B against the predicted model P26012: TM-score 0.98, RMSD 1.00 Å
- 6UJA chain B against the predicted model P26012: TM-score 0.98, RMSD 1.00 Å
- 6OM1 chain D against the predicted model P26012: TM-score 0.98, RMSD 0.94 Å
- 6OM1 chain D against the predicted model P26012: TM-score 0.98, RMSD 0.94 Å
- 8VSD chain B against the predicted model P26012: TM-score 0.98, RMSD 1.00 Å
- 6OM1 chain B against the predicted model P26012: TM-score 0.98, RMSD 1.00 Å
- 6OM1 chain B against the predicted model P26012: TM-score 0.98, RMSD 1.00 Å
Elsewhere
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