UniProt P25515
V-type proton ATPase subunit c (P25515)
V-type proton ATPase subunit c (UniProt P25515): 29 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P25515
- Protein
- V-type proton ATPase subunit c
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 38 · 4 records with a druggable one
Structures
30 records of P25515 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J9T | Yeast V-ATPase state 1 | electron microscopy | Y, R, U, V, T, W, S, X, Z, a | — | — |
| 3J9U | Yeast V-ATPase state 2 | electron microscopy | U, X, a, R, Z, S, Y, T, V, W | — | — |
| 3J9V | Yeast V-ATPase state 3 | electron microscopy | R, U, X, Y, W, Z, V, a, S, T | — | — |
| 5TJ5 | Atomic model for the membrane-embedded motor of a eukaryotic V-ATPase | electron microscopy | E, F, G, H, I, J, M, N | — | — |
| 5VOX | Yeast V-ATPase in complex with legionella pneumophila effector sidk (rotational state 1) | electron microscopy | T, U, V, W, X, Y, Z, a | — | — |
| 5VOY | Yeast V-ATPase in complex with legionella pneumophila effector sidk (rotational state 2) | electron microscopy | T, U, V, W, X, Y, Z, a | — | — |
| 5VOZ | Yeast V-ATPase in complex with legionella pneumophila effector sidk (rotational state 3) | electron microscopy | T, U, V, W, X, Y, Z, a | — | — |
| 6C6L | Yeast vacuolar ATPase vo in lipid nanodisc | electron microscopy | E, F, G, H, I, J, K, L | — | — |
| 6M0R | 2.7A yeast vo STATE3 | electron microscopy | E, F, G, H, I, J, K, L | PEE | — |
| 6M0S | 3.6A Yeast Vo state3 prime | electron microscopy | E, F, G, H, I, J, K, L | — | 14 (best 0.81) |
| 6M0S | 3.6A yeast vo STATE3 prime | electron microscopy | E, F, G, H, I, J, K, L | — | — |
| 6O7T | Saccharomyces cerevisiae V-ATPase Vph1-VO | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6O7T | Saccharomyces cerevisiae V-ATPase VPH1-vo | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6O7U | Saccharomyces cerevisiae V-ATPase STV1-vo | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6O7V | Saccharomyces cerevisiae V-ATPase STV1-V1VO state 1 | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6O7W | Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 2 | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6O7W | Saccharomyces cerevisiae V-ATPase STV1-V1VO state 2 | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6O7X | Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 3 | electron microscopy | g, h, i, j, k, l, m, n | — | 2 (best 0.84) |
| 6O7X | Saccharomyces cerevisiae V-ATPase STV1-V1VO state 3 | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 6PE4 | Yeast Vo motor in complex with 1 VopQ molecule | electron microscopy | I, J, K, L, M, N, O, P | — | 13 (best 0.82) |
| 6PE4 | Yeast vo motor in complex with 1 vopq molecule | electron microscopy | I, J, K, L, M, N, O, P | — | — |
| 6PE5 | Yeast vo motor in complex with 2 vopq molecules | electron microscopy | I, J, K, L, M, N, O, P | — | — |
| 7FDA | Cryoem structure of reconstituted V-ATPase, STATE1 | electron microscopy | V, W, X, Y, Z, a, b, c | — | — |
| 7FDB | Cryoem structures of reconstituted V-ATPASE,STATE2 | electron microscopy | V, W, X, Y, Z, a, b, c | — | — |
| 7FDC | Cryoem structures of reconstituted V-ATPase, STATE3 | electron microscopy | V, W, X, Y, Z, a, b, c | — | — |
| 7TAO | Cryo-EM structure of bafilomycin A1 bound to yeast vo V-ATPase | electron microscopy | E, F, G, H, I, J, K, L | WEV | — |
| 7TAP | Cryo-EM structure of archazolid a bound to yeast vo V-ATPase | electron microscopy | E, F, G, H, I, J, K, L | KJL | — |
| 7TMR | V-ATPase from saccharomyces cerevisiae, state 1 | electron microscopy | g, h, i, j, k, l, m, n | — | — |
| 8EAT | Yeast VO missing subunits a, e, and f in complex with Vma12-22p | electron microscopy | g, h, i, j, k, l, m, n | — | 9 (best 0.76) |
| P25515 | AlphaFold monomer V2.0 prediction for V-type proton ATPase subunit C (P25515) | predicted | A | — | — |
Ligands
- KJL · Archazolid A · in 1 record
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
- WEV · (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S, 4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7, 9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12, 14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose · in 1 record
Experiment against prediction
- 6PE4 chain O against the predicted model P25515: TM-score 0.99, RMSD 0.46 Å
- 6PE4 chain O against the predicted model P25515: TM-score 0.99, RMSD 0.46 Å
- 6PE5 chain I against the predicted model P25515: TM-score 0.99, RMSD 0.51 Å
- 6PE4 chain L against the predicted model P25515: TM-score 0.99, RMSD 0.53 Å
- 6PE4 chain M against the predicted model P25515: TM-score 0.99, RMSD 0.54 Å
- 6PE4 chain I against the predicted model P25515: TM-score 0.99, RMSD 0.56 Å
- 6PE4 chain I against the predicted model P25515: TM-score 0.99, RMSD 0.56 Å
- 6O7X chain g against the predicted model P25515: TM-score 0.99, RMSD 0.55 Å
- 6O7X chain g against the predicted model P25515: TM-score 0.99, RMSD 0.55 Å
- 6O7W chain g against the predicted model P25515: TM-score 0.99, RMSD 0.55 Å
Elsewhere
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