UniProt P23709
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (P23709)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (UniProt P23709), EC 1.6.5.3, 1.6.99.3: 38 experimental structures and 1 predicted model on GenesisL1, 104 pockets. Binding sites, druggability and experiment…
- UniProt
- P23709
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3, 7.1.1.2
- Experimental structures
- 38
- Predicted models
- 1
- Pockets
- 104 · 22 records with a druggable one
Structures
39 records of P23709 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LC5 | Structure of mammalian respiratory complex I, CLASS2 | electron microscopy | C | — | — |
| 5LDW | Structure of mammalian respiratory Complex I, class1 | electron microscopy | C | — | — |
| 5LDW | Structure of mammalian respiratory complex I, CLASS1 | electron microscopy | C | — | — |
| 5LDX | Structure of mammalian respiratory complex I, CLASS3. | electron microscopy | C | — | — |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | C | — | 4 (best 0.87) |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | C | — | — |
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | C | — | 2 (best 0.85) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | C | — | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | C | — | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | C2 | — | 2 (best 0.88) |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | C | — | 4 (best 0.89) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | C | — | — |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | C | — | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | C | — | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | C | — | 4 (best 0.90) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | C | — | — |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | C | — | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | C | — | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | C | — | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | C | — | 5 (best 0.90) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | C | — | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | C | — | 6 (best 0.89) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | C | — | 5 (best 0.90) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | C | — | 5 (best 0.90) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | C | — | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | C | — | 5 (best 0.88) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | C | — | 5 (best 0.90) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | C | — | 5 (best 0.90) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | C | — | 4 (best 0.89) |
| 8Q0F | Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | C | — | 5 (best 0.89) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | C | — | 5 (best 0.88) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | C | — | 6 (best 0.87) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | C | — | 6 (best 0.88) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | C | — | 4 (best 0.88) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | C | — | 5 (best 0.86) |
| 8Q46 | Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | C | — | 5 (best 0.90) |
| 8Q47 | Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. | electron microscopy | C | — | 6 (best 0.90) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | C | — | 6 (best 0.88) |
| P23709 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 3… | predicted | A | — | — |
Experiment against prediction
- 7R48 chain C against the predicted model P23709: TM-score 0.99, RMSD 0.41 Å
- 7R4G chain C against the predicted model P23709: TM-score 0.99, RMSD 0.42 Å
- 7R4C chain C against the predicted model P23709: TM-score 0.99, RMSD 0.42 Å
- 7R47 chain C against the predicted model P23709: TM-score 0.99, RMSD 0.42 Å
- 7R46 chain C against the predicted model P23709: TM-score 0.99, RMSD 0.42 Å
- 7R45 chain C against the predicted model P23709: TM-score 0.99, RMSD 0.42 Å
- 8Q4A chain C against the predicted model P23709: TM-score 0.99, RMSD 0.50 Å
- 7QSM chain C against the predicted model P23709: TM-score 0.99, RMSD 0.52 Å
- 7QSM chain C against the predicted model P23709: TM-score 0.99, RMSD 0.52 Å
- 8Q47 chain C against the predicted model P23709: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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