UniProt P23254
Transketolase (P23254)
Transketolase (UniProt P23254), EC 2.2.1.1: 14 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 181 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23254
- Protein
- Transketolase
- EC
- 2.2.1.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 181 · 15 records with a druggable one
Structures
15 records of P23254 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AY0 | Identification of catalytically important residues in yeast transketolase | x-ray diffraction | A, B | CA, TPP | 13 (best 0.80) |
| 1AY0 | Identification of catalytically important residues in yeast transketolase | x-ray diffraction | A, B | CA, TPP | 13 (best 0.80) |
| 1GPU | Transketolase complex with reaction intermediate | x-ray diffraction | A, B | CA, THD | 12 (best 0.80) |
| 1GPU | Transketolase complex with reaction intermediate | x-ray diffraction | A, B | CA, THD | 12 (best 0.80) |
| 1NGS | Complex of transketolase with thiamin diphosphate, CA2+ and acceptor substrate erythrose-4-phosphate | x-ray diffraction | A, B | CA, E4P, TPP | 12 (best 0.80) |
| 1NGS | Complex of transketolase with thiamin diphosphate, CA2+ and acceptor substrate erythrose-4-phosphate | x-ray diffraction | A, B | CA, E4P, TPP | 12 (best 0.80) |
| 1TKA | Specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of… | x-ray diffraction | A, B | CA, N3T | 13 (best 0.80) |
| 1TKA | Specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of… | x-ray diffraction | A, B | CA, N3T | 13 (best 0.80) |
| 1TKB | Specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of… | x-ray diffraction | A, B | CA, N1T | 13 (best 0.80) |
| 1TKB | Specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of… | x-ray diffraction | A, B | CA, N1T | 13 (best 0.80) |
| 1TKC | Specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of… | x-ray diffraction | A, B | CA, M6T | 13 (best 0.81) |
| 1TKC | Specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of… | x-ray diffraction | A, B | CA, M6T | 13 (best 0.81) |
| 1TRK | Refined structure of transketolase from saccharomyces cerevisiae at 2.0 ångströms resolution | x-ray diffraction | A, B | CA, TPP | 12 (best 0.79) |
| 1TRK | Refined structure of transketolase from saccharomyces cerevisiae at 2.0 ångströms resolution | x-ray diffraction | A, B | CA, TPP | 12 (best 0.79) |
| P23254 | AlphaFold monomer V2.0 prediction for transketolase 1 (P23254) | predicted | A | — | 5 (best 0.55) |
Ligands
- CA · Calcium ion · in 14 records
- TPP · Thiamine diphosphate · in 6 records
- E4P · Erythose-4-phosphate · in 2 records
- M6T · 6'-methyl-thiamin diphosphate · in 2 records
- N1T · 1'-deazo-thiamin diphosphate · in 2 records
- N3T · 3'-deazo-thiamin diphosphate · in 2 records
- THD · 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-2-(1,2-dihydroxyethyl)-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl trihydrogen diphosphate · in 2 records
Experiment against prediction
- 1GPU chain A against the predicted model P23254: TM-score 1.00, RMSD 0.43 Å
- 1GPU chain A against the predicted model P23254: TM-score 1.00, RMSD 0.43 Å
- 1TRK chain A against the predicted model P23254: TM-score 1.00, RMSD 0.44 Å
- 1TRK chain A against the predicted model P23254: TM-score 1.00, RMSD 0.44 Å
- 1NGS chain A against the predicted model P23254: TM-score 1.00, RMSD 0.45 Å
- 1NGS chain A against the predicted model P23254: TM-score 1.00, RMSD 0.45 Å
- 1TKC chain A against the predicted model P23254: TM-score 1.00, RMSD 0.48 Å
- 1TKC chain A against the predicted model P23254: TM-score 1.00, RMSD 0.48 Å
- 1TKB chain A against the predicted model P23254: TM-score 1.00, RMSD 0.49 Å
- 1TKB chain A against the predicted model P23254: TM-score 1.00, RMSD 0.49 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.