UniProt P22262
Listeriolysin regulatory protein (P22262)
Listeriolysin regulatory protein (UniProt P22262): 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22262
- Protein
- Listeriolysin regulatory protein
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 5 · 2 records with a druggable one
Structures
17 records of P22262 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OMI | Crystal structure of PrfA,the transcriptional regulator in Listeria monocytogenes | x-ray diffraction | A, B | — | — |
| 1OMI | Crystal structure of PRFA,THE transcriptional regulator in listeria monocytogenes | x-ray diffraction | A, B | — | — |
| 2BEO | PrfA, Transcriptional Regulator In Listeria Monocytogenes | x-ray diffraction | A, B | — | — |
| 2BEO | Prfa, transcriptional regulator in listeria monocytogenes | x-ray diffraction | A, B | — | — |
| 2BGC | PrfA-G145S, a constitutive active mutant of the Transcriptional Regulator In L.monocytogenes | x-ray diffraction | A, B, D, E, F, G, H, I | — | — |
| 2BGC | Prfa-G145S, a constitutive active mutant of the transcriptional regulator in L.MONOCYTOGENES | x-ray diffraction | A, B, D, E, F, G, H, I | — | — |
| 5F1R | The transcriptional regulator prfa from listeria monocytogenes in complex with a ring-fused… | x-ray diffraction | A, B | — | — |
| 5LEJ | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a 30-bp operator… | x-ray diffraction | A, B | — | — |
| 5LEJ | The transcriptional regulator prfa from listeria monocytogenes in complex with a 30-bp operator… | x-ray diffraction | A, B | — | — |
| 5LEK | The Transcriptional Regulator PrfA-G145S mutant from Listeria Monocytogenes in complex with a 30-bp… | x-ray diffraction | A, B | — | — |
| 5LEK | The transcriptional regulator prfa-G145S mutant from listeria monocytogenes in complex with a 30-bp… | x-ray diffraction | A, B | — | — |
| 6EUT | The transcriptional regulator prfa from listeria monocytogenes in complex with a ring-fused… | x-ray diffraction | A, B | BY8, NA | — |
| 6EV0 | The transcriptional regulator prfa from listeria monocytogenes in complex with a ring-fused… | x-ray diffraction | A, B | BYK, C8N | — |
| 6EXK | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused… | x-ray diffraction | A, B | C2Q, NA | 2 (best 0.83) |
| 6EXK | The transcriptional regulator prfa from listeria monocytogenes in complex with a ring-fused… | x-ray diffraction | A, B | C2Q, NA | — |
| 6HCK | The transcriptional regulator prfa from listeria monocytogenes in complex with dipeptide leu-leu | x-ray diffraction | A, B | NA | — |
| P22262 | AlphaFold monomer V2.0 prediction for listeriolysin regulatory protein (P22262) | predicted | A | — | 3 (best 0.66) |
Ligands
- NA · Sodium ion · in 4 records
- C2Q · [(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium · in 2 records
- BY8 · (3~{R})-8-cyclopropyl-7-[(4-methylnaphthalen-1-yl) methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid · in 1 record
- BYK · [(3~{R})-3-carboxy-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium · in 1 record
- C8N · [(3~{S})-3-carboxy-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium · in 1 record
Experiment against prediction
- 5LEJ chain A against the predicted model P22262: TM-score 0.97, RMSD 1.06 Å
- 5LEJ chain A against the predicted model P22262: TM-score 0.97, RMSD 1.06 Å
- 5LEK chain A against the predicted model P22262: TM-score 0.97, RMSD 1.06 Å
- 5LEK chain A against the predicted model P22262: TM-score 0.97, RMSD 1.06 Å
- 5LEJ chain B against the predicted model P22262: TM-score 0.97, RMSD 1.07 Å
- 5LEJ chain B against the predicted model P22262: TM-score 0.97, RMSD 1.07 Å
- 2BGC chain B against the predicted model P22262: TM-score 0.97, RMSD 1.18 Å
- 2BGC chain B against the predicted model P22262: TM-score 0.97, RMSD 1.18 Å
- 2BGC chain F against the predicted model P22262: TM-score 0.97, RMSD 1.20 Å
- 2BGC chain F against the predicted model P22262: TM-score 0.97, RMSD 1.20 Å
Elsewhere
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