MolNFT v1 · #151068 · protein
The transcriptional regulator prfa from listeria monocytogenes in complex with dipeptide leu-leu
6HCK · Listeriolysin regulatory protein: “The transcriptional regulator prfa from listeria monocytogenes in complex with dipeptide leu-leu”. X-ray diffraction, 1 ligand (NA), 2 pockets (best druggability 0.85). MolNFT v1 #151068 on…
- PDB
- 6HCK
- Type
- protein
- Length
- 463 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Listeriolysin regulatory protein
- UniProt
- P22262
- Ligands
- NA
- Pockets
- 2 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Listeriolysin regulatory protein | protein | 234 | 46% helix, 27% strand | P22262 |
| B | Listeriolysin regulatory protein | protein | 229 | 46% helix, 25% strand | P22262 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 977 | 0.85 | 0.86 | 98 | empty |
| 2 | 215 | 0.57 | 0.79 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 2178 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6HCK · The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with dipeptide… · the same entry in another collection · chain A against A, TM-score 1.00
- P22262 · AlphaFold monomer V2.0 prediction for listeriolysin regulatory protein (P22262) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22262
- Elsewhere: RCSB PDB 6HCK · PDBe 6HCK · UniProt P22262
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