UniProt P21852
Periplasmic [NiFe] hydrogenase large subunit (P21852)
Periplasmic [NiFe] hydrogenase large subunit (UniProt P21852), EC 1.12.2.1: 45 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P21852
- Protein
- Periplasmic [NiFe] hydrogenase large subunit
- EC
- 1.12.2.1
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 35 · 3 records with a druggable one
Structures
46 records of P21852 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H2A | Single crystals of hydrogenase from desulfovibrio vulgaris | x-ray diffraction | L | — | — |
| 1H2A | Single crystals of hydrogenase from desulfovibrio vulgaris | x-ray diffraction | L | — | — |
| 1H2R | Three-dimensional structure of ni-fe hydrogenase from desulfivibrio vulgaris miyazaki F in the… | x-ray diffraction | L | — | — |
| 1H2R | Three-dimensional structure of ni-fe hydrogenase from desulfivibrio vulgaris miyazaki F in the… | x-ray diffraction | L | — | — |
| 1UBH | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBH | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBJ | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBJ | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBK | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBK | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBL | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBL | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBM | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBM | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBO | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBO | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBR | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBR | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBT | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBT | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBU | Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From Desulufovibrio… | x-ray diffraction | L | — | — |
| 1UBU | Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from desulufovibrio… | x-ray diffraction | L | — | — |
| 1WUH | Three-Dimensional Structure Of The Ni-A State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 1WUH | Three-dimensional structure of the ni-a state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 1WUI | Ultra-High resolution Structure Of The Ni-A State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 1WUI | Ultra-high resolution structure of the ni-a state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 1WUJ | Three-Dimensional Structure Of The Ni-B State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 1WUJ | Three-dimensional structure of the ni-B state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 1WUK | High resolution Structure Of The Oxidized State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 1WUK | High resolution structure of the oxidized state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 1WUL | High Resolution Structure Of The Reduced State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 1WUL | High resolution structure of the reduced state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 4U9H | Ultra High Resolution Structure Of The Ni-R State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 4U9H | Ultra high resolution structure of the ni-R state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 4U9I | High Resolution Structure Of The Ni-R State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris… | x-ray diffraction | L | — | — |
| 4U9I | High resolution structure of the ni-R state of [NIFE]HYDROGENASE from desulufovibrio vulgaris… | x-ray diffraction | L | — | — |
| 5XLE | Crystal structure of anaerobically purified and anaerobically crystallized D. vulgaris miyazaki F… | x-ray diffraction | L | SF4, F3S, NFU, MG | — |
| 5XLF | Crystal structure of aerobically purified and aerobically crystallized D. vulgaris Miyazaki F… | x-ray diffraction | L | SF4, F3S, NFV, MG | 7 (best 0.53) |
| 5XLF | Crystal structure of aerobically purified and aerobically crystallized D. vulgaris miyazaki F… | x-ray diffraction | L | SF4, F3S, NFV, MG | — |
| 5XLG | Crystal structure of anaerobically purified and aerobically crystallized D. vulgaris Miyazaki F… | x-ray diffraction | L | SF4, F3S, NFV, MG | 8 (best 0.78) |
| 5XLG | Crystal structure of anaerobically purified and aerobically crystallized D. vulgaris miyazaki F… | x-ray diffraction | L | SF4, F3S, NFV, MG | — |
| 5XLH | Crystal structure of aerobically purified and aerobically crystallized for 12weeks D. vulgaris… | x-ray diffraction | L | SF4, F3S, NFV, MG | 8 (best 0.77) |
| 5XLH | Crystal structure of aerobically purified and aerobically crystallized for 12WEEKS D. vulgaris… | x-ray diffraction | L | SF4, F3S, NFV, MG | — |
| 5Y4N | Crystal structure of aerobically purified and anaerobically crystallized D. vulgaris miyazaki F… | x-ray diffraction | L | SF4, F3S, MG, NFU | — |
| 8W6X | Neutron structure of [NiFe]-hydrogenase from D. vulgaris Miyazaki F in its oxidized state | x-ray diffraction, neutron diffraction | L | NFU, OH, MG, CL, SF4, F3S | 7 (best 0.49) |
| P21852 | AlphaFold monomer V2.0 prediction for periplasmic [nife] hydrogenase large subunit (P21852) | predicted | A | — | 5 (best 0.46) |
Ligands
Experiment against prediction
- 8W6X chain L against the predicted model P21852: TM-score 1.00, RMSD 0.24 Å
- 4U9H chain L against the predicted model P21852: TM-score 1.00, RMSD 0.25 Å
- 4U9H chain L against the predicted model P21852: TM-score 1.00, RMSD 0.25 Å
- 5XLH chain L against the predicted model P21852: TM-score 1.00, RMSD 0.25 Å
- 5XLH chain L against the predicted model P21852: TM-score 1.00, RMSD 0.25 Å
- 5XLF chain L against the predicted model P21852: TM-score 1.00, RMSD 0.27 Å
- 5XLF chain L against the predicted model P21852: TM-score 1.00, RMSD 0.27 Å
- 5XLE chain L against the predicted model P21852: TM-score 1.00, RMSD 0.27 Å
- 4U9I chain L against the predicted model P21852: TM-score 1.00, RMSD 0.29 Å
- 4U9I chain L against the predicted model P21852: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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