MolNFT v1 · #298195 · protein
AlphaFold monomer V2.0 prediction for periplasmic [nife] hydrogenase large subunit (P21852)
P21852: “AlphaFold monomer V2.0 prediction for periplasmic [nife] hydrogenase large subunit (P21852)”. 5 pockets (best druggability 0.46). MolNFT v1 #298195 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P21852
- Type
- protein
- Length
- 567 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB0d7400b9DcfaC79853F2a70119e45D7974F7358
- Molecule
- Periplasmic [nife] hydrogenase large subunit
- UniProt
- P21852
- Pockets
- 5 · best druggability 0.46
Structure
1 distinct chain · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Periplasmic [nife] hydrogenase large subunit | protein | 567 | 45% helix, 14% strand | P21852 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.46 | 0.85 | 15 | empty |
| 2 | 139 | 0.41 | 0.74 | 20 | empty |
| 3 | 80 | 0.38 | 0.77 | 19 | empty |
| 4 | 82 | 0.29 | 0.72 | 19 | empty |
| 5 | 59 | 0.27 | 0.72 | 18 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1WUK · High resolution structure of the oxidized state of [NIFE]HYDROGENASE from desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUK · High resolution Structure Of The Oxidized State Of [Nife]Hydrogenase From Desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUI · Ultra-High resolution Structure Of The Ni-A State Of [Nife]Hydrogenase From… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUI · Ultra-high resolution structure of the ni-a state of [NIFE]HYDROGENASE from… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUH · Three-Dimensional Structure Of The Ni-A State Of [Nife]Hydrogenase From Desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUH · Three-dimensional structure of the ni-a state of [NIFE]HYDROGENASE from desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1UBM · Three-dimensional structure of the carbon monoxide complex of [NIFE]HYDROGENASE from… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1UBM · Three-dimensional Structure of The Carbon Monoxide Complex of [NiFe]hydrogenase From… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUJ · Three-Dimensional Structure Of The Ni-B State Of [Nife]Hydrogenase From Desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUJ · Three-dimensional structure of the ni-B state of [NIFE]HYDROGENASE from desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUL · High Resolution Structure Of The Reduced State Of [Nife]Hydrogenase From Desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
- 1WUL · High resolution structure of the reduced state of [NIFE]HYDROGENASE from desulufovibrio… · an experimental structure of the same protein · chain A against L, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21852
- Elsewhere: UniProt P21852 · AlphaFold DB P21852
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