UniProt P18669
Phosphoglycerate mutase 1 (P18669)
Phosphoglycerate mutase 1 (UniProt P18669), EC 5.4.2.11, 5.4.2.4: 33 experimental structures and 1 predicted model on GenesisL1, 19 ligands bound, 65 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P18669
- Protein
- Phosphoglycerate mutase 1
- EC
- 5.4.2.11, 5.4.2.4
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 19
- Pockets
- 65 · 13 records with a druggable one
Structures
34 records of P18669 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YFK | Crystal structure of human B type phosphoglycerate mutase | x-ray diffraction | A, B | — | — |
| 1YFK | Crystal structure of human B type phosphoglycerate mutase | x-ray diffraction | A, B | — | — |
| 1YJX | Crystal structure of human B type phosphoglycerate mutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1YJX | Crystal structure of human B type phosphoglycerate mutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4GPI | Crystal structure of human B type phosphoglycerate mutase | x-ray diffraction | B, C | — | — |
| 4GPI | Crystal structure of human B type phosphoglycerate mutase | x-ray diffraction | B, C | — | — |
| 4GPZ | Crystal structure of human B type phosphoglycerate mutase H11 phosphorylated form | x-ray diffraction | A, B | — | — |
| 4GPZ | Crystal structure of human B type phosphoglycerate mutase H11 phosphorylated form | x-ray diffraction | A, B | — | — |
| 5Y2I | Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A | x-ray diffraction | B, C | 8KX, CL | — |
| 5Y2I | Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor pgmi- 004A | x-ray diffraction | B, C | 8KX, CL | — |
| 5Y2U | X-ray structure of phosphoglycerate mutase 1(PGAM1) complexed with a small molecule | x-ray diffraction | B, C | CL, AZN | — |
| 5Y35 | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH1 | x-ray diffraction | B, C | CL, 8LF | — |
| 5Y35 | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH1 | x-ray diffraction | B, C | CL, 8LF | — |
| 5Y64 | Phosphoglycerate mutase 1 H11 phosphorylated form complexed with KH1 | x-ray diffraction | B, C | CL, 8LF | — |
| 5Y65 | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH2 | x-ray diffraction | B, C | CL, HKB | — |
| 5Y65 | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH2 | x-ray diffraction | B, C | CL, HKB | — |
| 5ZRM | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor In-AC | x-ray diffraction | B, C | CL, 9HU | 5 (best 0.63) |
| 5ZRM | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor in-ac | x-ray diffraction | B, C | CL, 9HU | — |
| 5ZS7 | Acetylation of lysine 100 in Phosphoglycerate mutase 1 | x-ray diffraction | B, C | CL | 6 (best 0.55) |
| 5ZS7 | Acetylation of lysine 100 in phosphoglycerate mutase 1 | x-ray diffraction | B, C | CL | — |
| 5ZS8 | Acetylation of lysine 100 of phosphoglycerate mutase 1 complexed with KH_OL | x-ray diffraction | B, C | CL, 9JF | — |
| 6ISN | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor | x-ray diffraction | B, C | CL, AW6 | — |
| 7XB7 | Phosphoglycerate mutase 1 complexed with a covalent inhibitor | x-ray diffraction | B, C | CL, CKF | — |
| 7XB8 | Phosphoglycerate mutase 1 complexed with a covalent inhibitor | x-ray diffraction | B, C | CL, H6I | 6 (best 0.68) |
| 7XB9 | Phosphoglycerate mutase 1 complexed with a covalent inhibitor | x-ray diffraction | B, C | CL, H5X | 6 (best 0.62) |
| 8IT4 | Phosphoglycerate mutase 1 complexed with a covalent inhibitor | x-ray diffraction | A, B | CL, SKU | 5 (best 0.64) |
| 8IT5 | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, QAI | 5 (best 0.61) |
| 8IT6 | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, Q90 | 5 (best 0.61) |
| 8IT7 | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, Q9F | 5 (best 0.59) |
| 8IT8 | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, Q9L | 5 (best 0.62) |
| 8ITB | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, Q9R | 5 (best 0.60) |
| 8ITC | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, QA0 | 5 (best 0.60) |
| 8ITD | Phosphoglycerate mutase 1 complexed with a compound | x-ray diffraction | B, C | CL, QA3 | 6 (best 0.59) |
| P18669 | AlphaFold monomer V2.0 prediction for phosphoglycerate mutase 1 (P18669) | predicted | A | — | 1 (best 0.74) |
Ligands
- CL · Chloride ion · in 25 records
- 8LF · ~{N}-[3,4-bis(oxidanyl)-9,10-bis(oxidanylidene) anthracen-2-yl]-4-methyl-benzenesulfonamide · in 3 records
- 8KX · 3,4-bis(oxidanyl)-9,10-bis(oxidanylidene)-~{N}-[4-(trifluoromethyl)phenyl]anthracene-2-sulfonamide · in 2 records
- 9HU · 2-[(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)sulfamoyl]phenyl acetate · in 2 records
- HKB · ~{N}-[3,4-bis(oxidanyl)-9,10-bis(oxidanylidene) anthracen-2-yl]-4-(dimethylamino)benzenesulfonamide · in 2 records
- 9JF · N-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)-2-hydroxybenzene-1-sulfonamide · in 1 record
- AW6 · 4-chloro-N-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)benzene-1-sulfonamide · in 1 record
- AZN · Alizarin red · in 1 record
- CKF · 3-[[5-(cyclopenten-1-yl)-2-(methylcarbamoyl)phenyl]sulfamoyl]benzenesulfonic acid · in 1 record
- H5X · 3-[[5-(cyclopenten-1-yl)-2-methoxycarbonyl-phenyl]sulfamoyl]benzenesulfonic acid · in 1 record
- H6I · 4-(cyclopenten-1-yl)-2-[(3-sulfophenyl)sulfonylamino]benzoic acid · in 1 record
- Q90 · 4-[4-chloranyl-2-(2-hydroxy-2-oxoethyloxy)phenyl]-2-[(4-phenylphenyl)sulfonylamino]benzoic acid · in 1 record
- Q9F · 4-(4-chlorophenyl)-2-oxidanyl-6-[(4-phenylphenyl)sulfonylamino]benzoic acid · in 1 record
- Q9L · 4-(4-chlorophenyl)-2-[(4-phenylphenyl)sulfonylamino]benzoic acid · in 1 record
- Q9R · 5-(3-chloranyl-4-fluoranyl-phenyl)-2-oxidanyl-3-[(4-phenylphenyl)sulfonylamino]benzoic acid · in 1 record
- QA0 · 5-(4-chlorophenyl)-3-[(4-phenylphenyl)sulfonylamino]phthalic acid · in 1 record
- QA3 · 4-(4-chloranyl-2-oxidanyl-phenyl)-2-[(4-phenylphenyl)sulfonylamino]benzoic acid · in 1 record
- QAI · 5-(4-chlorophenyl)-3-[(4-phenylphenyl)sulfonylamino]thiophene-2-carboxylic acid · in 1 record
- SKU · 3-[[5-(4-chlorophenyl)-2-methoxycarbonyl-thiophen-3-yl]sulfamoyl]benzenesulfonic acid · in 1 record
Experiment against prediction
- 4GPZ chain B against the predicted model P18669: TM-score 0.99, RMSD 0.56 Å
- 4GPZ chain B against the predicted model P18669: TM-score 0.99, RMSD 0.56 Å
- 4GPI chain C against the predicted model P18669: TM-score 0.99, RMSD 0.63 Å
- 4GPI chain C against the predicted model P18669: TM-score 0.99, RMSD 0.63 Å
- 1YFK chain A against the predicted model P18669: TM-score 0.99, RMSD 0.67 Å
- 1YFK chain A against the predicted model P18669: TM-score 0.99, RMSD 0.67 Å
- 1YJX chain K against the predicted model P18669: TM-score 0.99, RMSD 0.68 Å
- 1YJX chain K against the predicted model P18669: TM-score 0.99, RMSD 0.68 Å
- 5ZS7 chain C against the predicted model P18669: TM-score 0.98, RMSD 0.83 Å
- 5ZS7 chain C against the predicted model P18669: TM-score 0.98, RMSD 0.83 Å
Elsewhere
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