MolNFT v1 · #142067 · protein
Acetylation of lysine 100 in phosphoglycerate mutase 1
5ZS7: “Acetylation of lysine 100 in phosphoglycerate mutase 1”. X-ray diffraction, 1 ligand (CL), 6 pockets (best druggability 0.55). MolNFT v1 #142067 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZS7
- Type
- protein
- Length
- 467 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoglycerate mutase 1
- EC
- 5.4.2.11, 5.4.2.4
- UniProt
- P18669
- Ligands
- CL
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Phosphoglycerate mutase 1 (EC 5.4.2.11, 5.4.2.4) | protein | 233 | 45% helix, 13% strand | P18669 |
| C | Phosphoglycerate mutase 1 (EC 5.4.2.11, 5.4.2.4) | protein | 234 | 44% helix, 14% strand | P18669 |
Ligands and binding sites
- CL · Chloride ion · ion · chains B, C
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.55 | 0.78 | 27 | empty |
| 2 | 228 | 0.53 | 0.77 | 24 | MES |
| 3 | 153 | 0.44 | 0.75 | 18 | empty |
| 4 | 143 | 0.42 | 0.74 | 20 | empty |
| 5 | 95 | 0.37 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- B–C · 1098 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (acetylation, phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18669
- Elsewhere: RCSB PDB 5ZS7 · PDBe 5ZS7 · UniProt P18669
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.