UniProt P18031
Tyrosine-protein phosphatase non-receptor type 1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (UniProt P18031), EC 3.1.3.48: 498 experimental structures on GenesisL1, 125 ligands bound, 65 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P18031
- Protein
- Tyrosine-protein phosphatase non-receptor type 1
- EC
- 3.1.3.48
- Experimental structures
- 498
- Predicted models
- 0
- Ligands
- 125
- Pockets
- 65 · 4 records with a druggable one
Structures
498 records of P18031 in the MolNFT archive: 498 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A5Y | Protein tyrosine phosphatase 1B cysteinyl-phosphate intermediate | x-ray diffraction | A | — | — |
| 1A5Y | Protein tyrosine phosphatase 1B cysteinyl-phosphate intermediate | x-ray diffraction | A | — | — |
| 1AAX | Crystal structure of protein tyrosine phosphatase 1B complexed with two… | x-ray diffraction | A | — | — |
| 1AAX | Crystal structure of protein tyrosine phosphatase 1B complexed with two… | x-ray diffraction | A | — | — |
| 1BZC | Human PTP1B catalytic domain complexed with tpi | x-ray diffraction | A | — | — |
| 1BZC | Human PTP1B catalytic domain complexed with tpi | x-ray diffraction | A | — | — |
| 1BZH | Cyclic peptide inhibitor of human PTP1B | x-ray diffraction | A | — | — |
| 1BZH | Cyclic peptide inhibitor of human PTP1B | x-ray diffraction | A | — | — |
| 1BZJ | Human ptp1b complexed with tpicooh | x-ray diffraction | A | — | — |
| 1BZJ | Human PTP1B complexed with tpicooh | x-ray diffraction | A | — | — |
| 1C83 | Crystal structure of protein tyrosine phosphatase 1B complexed with… | x-ray diffraction | A | — | — |
| 1C83 | Crystal structure of protein tyrosine phosphatase 1B complexed with 6… | x-ray diffraction | A | — | — |
| 1C84 | Crystal structure of protein tyrosine phosphatase 1B complexed with… | x-ray diffraction | A | — | — |
| 1C84 | Crystal structure of protein tyrosine phosphatase 1B complexed with 3… | x-ray diffraction | A | — | — |
| 1C85 | Crystal structure of protein tyrosine phosphatase 1B complexed with 2-(oxalyl-amino)-benzoic acid | x-ray diffraction | A | — | — |
| 1C85 | Crystal structure of protein tyrosine phosphatase 1B complexed with 2- (oxalyl-amino)-benzoic acid | x-ray diffraction | A | — | — |
| 1C86 | Crystal structure of protein tyrosine phosphatase 1B (R47V,D48N) complexed with… | x-ray diffraction | A | — | — |
| 1C86 | Crystal structure of protein tyrosine phosphatase 1B (R47V,D48N) complexed with… | x-ray diffraction | A | — | — |
| 1C87 | Crystal structure of protein tyrosine phosphatase 1B complexed with… | x-ray diffraction | A | — | — |
| 1C87 | Crystal structure of protein tyrosine phosphatase 1B complexed with 2… | x-ray diffraction | A | — | — |
| 1C88 | Crystal structure of protein tyrosine phosphatase 1B complexed with… | x-ray diffraction | A | — | — |
| 1C88 | Crystal structure of protein tyrosine phosphatase 1B complexed with 2… | x-ray diffraction | A | — | — |
| 1ECV | Crystal structure of protein tyrosine phosphatase 1B complexed with 5-iodo-2-(oxalyl-amino)-benzoic… | x-ray diffraction | A | — | — |
| 1ECV | Crystal structure of protein tyrosine phosphatase 1B complexed with 5… | x-ray diffraction | A | — | — |
| 1EEN | Crystal structure of protein tyrosine phosphatase 1B complexed with… | x-ray diffraction | A | — | — |
| 1EEN | Crystal structure of protein tyrosine phosphatase 1B complexed with… | x-ray diffraction | A | — | — |
| 1EEO | Crystal structure of protein tyrosine phosphatase 1B complexed with acetyl-E-L-E-F-ptyr-M-D-Y-E-NH2 | x-ray diffraction | A | — | — |
| 1EEO | Crystal structure of protein tyrosine phosphatase 1B complexed with acetyl-E-L-E-F-ptyr-M-D-Y-E-NH2 | x-ray diffraction | A | — | — |
| 1G1F | Crystal structure of protein tyrosine phosphatase 1B complexed with a tri-phosphorylated peptide… | x-ray diffraction | A | — | — |
| 1G1F | Crystal structure of protein tyrosine phosphatase 1B complexed with a tri-phosphorylated peptide… | x-ray diffraction | A | — | — |
| 1G1G | Crystal structure of protein tyrosine phosphatase 1B complexed with a mono-phosphorylated peptide… | x-ray diffraction | A | — | — |
| 1G1G | Crystal structure of protein tyrosine phosphatase 1B complexed with a mono-phosphorylated peptide… | x-ray diffraction | A | — | — |
| 1G1H | Crystal structure of protein tyrosine phosphatase 1B complexed with a bis-phosphorylated peptide… | x-ray diffraction | A | — | — |
| 1G1H | Crystal structure of protein tyrosine phosphatase 1B complexed with a bis-phosphorylated peptide… | x-ray diffraction | A | — | — |
| 1G7F | Human PTP1B catalytic domain complexed with PNU177496 | x-ray diffraction | A | — | — |
| 1G7F | Human PTP1B catalytic domain complexed with PNU177496 | x-ray diffraction | A | — | — |
| 1G7G | Human PTP1B catalytic domain complexes with PNU179326 | x-ray diffraction | A | — | — |
| 1G7G | Human PTP1B catalytic domain complexes with PNU179326 | x-ray diffraction | A | — | — |
| 1GFY | Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatase 1B and… | x-ray diffraction | A | — | — |
| 1GFY | Residue 259 is a key determinant of substrate specificity of protein- tyrosine phosphatase 1B and… | x-ray diffraction | A | — | — |
| 1I57 | Crystal structure of apo human PTP1B (C215S) mutant | x-ray diffraction | A | — | — |
| 1I57 | Crystal structure of apo human PTP1B (C215S) mutant | x-ray diffraction | A | — | — |
| 1JF7 | Human PTP1B catalytic domain complexed with PNU177836 | x-ray diffraction | A, B | — | — |
| 1JF7 | Human PTP1B catalytic domain complexed with PNU177836 | x-ray diffraction | A, B | — | — |
| 1KAK | Human Tyrosine Phosphatase 1B Complexed with an Inhibitor | x-ray diffraction | A | — | — |
| 1KAK | Human tyrosine phosphatase 1B complexed with an inhibitor | x-ray diffraction | A | — | — |
| 1KAV | Human Tyrosine Phosphatase 1B Complexed with an Inhibitor | x-ray diffraction | A | — | — |
| 1KAV | Human tyrosine phosphatase 1B complexed with an inhibitor | x-ray diffraction | A | — | — |
| 1L8G | Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxaly… | x-ray diffraction | A | — | — |
| 1L8G | Crystal structure of PTP1B complexed with 7-(1,1-dioxo-1H… | x-ray diffraction | A | — | — |
| 1LQF | Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1LQF | Structure of PTP1B in complex with a peptidic bisphosphonate inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1NL9 | Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 12 Using a Linked-Fragment… | x-ray diffraction | A | — | — |
| 1NL9 | Potent, selective protein tyrosine phosphatase 1B inhibitor compound 12 using a linked-fragment… | x-ray diffraction | A | — | — |
| 1NNY | Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 23 Using a Linked-Fragment… | x-ray diffraction | A | — | — |
| 1NNY | Potent, selective protein tyrosine phosphatase 1B inhibitor compound 23 using a linked-fragment… | x-ray diffraction | A | — | — |
| 1NO6 | Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 5 Using a Linked-Fragment… | x-ray diffraction | A | — | — |
| 1NO6 | Potent, selective protein tyrosine phosphatase 1B inhibitor compound 5 using a linked-fragment… | x-ray diffraction | A | — | — |
| 1NWE | Ptp1B R47C Modified at C47 with N-[4-(2-{2-[3-(2-Bromo-acetylamino)-propionylamino]-3-hydroxy-propio… | x-ray diffraction | A | — | — |
| 1NWE | PTP1B R47C modified at C47 with N-[4-(2-{2-[3-(2-bromo-acetylamino)… | x-ray diffraction | A | — | — |
438 records more on the page itself.
Ligands
- CL · Chloride ion · in 39 records
- OTA · 2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid · in 20 records
- MG · Magnesium ion · in 12 records
- VO4 · Vanadate ion · in 9 records
- BEN · Benzamidine · in 7 records
- JK7 · N-[(1S,2S,3S,4R)-3-hydroxy-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl]cyclobutanecarboxamide · in 4 records
- JJP · (2S,5S,6R)-7-methyl-2,3,4,5,6,7-hexahydro-1H-2,6-methanoazocino[5,4-b]indol-5-ol · in 3 records
- JJY · 3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione · in 3 records
- JKA · (1S,4R,5S,6R)-2-(methylsulfonyl)-2-azabicyclo[3.3.1]nonane-4,6-diol · in 3 records
- JKG · 4-({[(thiophen-2-yl)methyl]amino}methyl)phenol · in 3 records
- WO4 · Tungstate(vi)ion · in 3 records
- AW7 · 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine · in 2 records
- AWD · ~{N}-(4-fluorophenyl)-4-methyl-piperazine-1-carboxamide · in 2 records
- D0P · N-(2',4'-difluoro-4-hydroxy[1,1'-biphenyl]-3-yl)-2-sulfanylacetamide · in 2 records
- H5A · 3,4,5-trimethoxybenzoic acid · in 2 records
- JFJ · 1-(3-chlorophenyl)-N-methylmethanamine · in 2 records
- JG4 · 2-(thiophen-2-yl)-1H-imidazole · in 2 records
- JHA · 3-chloro-4-(4-methylpiperidin-1-yl)aniline · in 2 records
- JKJ · (1R,3R,4S)-3-(methoxymethyl)-2-(methylsulfonyl)-2-azabicyclo[2.2.2]octan-4-ol · in 2 records
- JL4 · 5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxylic acid · in 2 records
- JLA · 4-(piperidin-1-yl)benzoic acid · in 2 records
- JMM · [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl) methanone · in 2 records
- JMY · 1-[(3S,3aS,8bS)-5-fluoro-3-(hydroxymethyl)-2,3,3a,8b-tetrahydro-1H-[1]benzofuro[3,2-b]pyrrol-1-yl]ethan-1-one · in 2 records
- JN1 · (6R)-5,6-dihydro-1H-2,6-methano-1lambda~6~-1lambda~6~,2,5-benzothiadiazocine-1,1,4(3H)-trione · in 2 records
- JNA · N-[(thiophen-2-yl)methyl]benzenesulfonamide · in 2 records
- JOA · (1R,4R,5R,6R)-4,6-dimethoxy-2-(methylsulfonyl)-2-azabicyclo[3.3.1]nonane · in 2 records
- JOP · N-[(1R,2S,4S)-bicyclo[2.2.1]heptan-2-yl]-N'-[(2R)-2-hydroxypropyl]thiourea · in 2 records
- JOV · 3-chloro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide · in 2 records
- JPD · methyl (1S,3S,4R)-4-hydroxy-3-[(1S)-1-hydroxypropyl]-2-azabicyclo[2.2.2]octane-2-carboxylate · in 2 records
- JPV · (2R,5R,6S)-2,3,4,5,6,7-hexahydro-1H-2,6-methanoazocino[5,4-b]indol-5-ol · in 2 records
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.