UniProt P16435
NADPH--cytochrome P450 reductase (P16435)
NADPH--cytochrome P450 reductase (UniProt P16435), EC 1.6.2.4: 18 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P16435
- Protein
- NADPH--cytochrome P450 reductase
- EC
- 1.6.2.4
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 18 · 2 records with a druggable one
Structures
19 records of P16435 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B1C | Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93A resolution | x-ray diffraction | A | — | — |
| 1B1C | Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93A resolution | x-ray diffraction | A | — | — |
| 3FJO | Structure of chimeric YH CPR | x-ray diffraction | A | — | — |
| 3FJO | Structure of chimeric yh cpr | x-ray diffraction | A | — | — |
| 3QE2 | Crystal Structure of Human NADPH-Cytochrome P450 Reductase | x-ray diffraction | A, B | — | — |
| 3QE2 | Crystal structure of human NADPH-cytochrome P450 reductase | x-ray diffraction | A, B | — | — |
| 3QFC | Crystal Structure of Human NADPH-Cytochrome P450 (V492E mutant) | x-ray diffraction | A, B | — | — |
| 3QFC | Crystal structure of human NADPH-cytochrome P450 (V492E mutant) | x-ray diffraction | A, B | — | — |
| 3QFR | Crystal Structure of Human NADPH-Cytochrome P450 Reductase (R457H Mutant) | x-ray diffraction | A, B | — | — |
| 3QFR | Crystal structure of human NADPH-cytochrome P450 reductase (R457H mutant) | x-ray diffraction | A, B | — | — |
| 3QFS | Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain) | x-ray diffraction | A | — | — |
| 3QFS | Crystal structure of NADPH-cytochrome P450 reductase (FAD/NADPH domain) | x-ray diffraction | A | — | — |
| 3QFT | Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain and R457H Mutant) | x-ray diffraction | A | — | — |
| 3QFT | Crystal structure of NADPH-cytochrome P450 reductase (FAD/NADPH domain and R457H mutant) | x-ray diffraction | A | — | — |
| 5EMN | Crystal Structure of Human NADPH-Cytochrome P450 Reductase(A287P mutant) | x-ray diffraction | A, B | FMN, FAD, NAP | — |
| 5EMN | Crystal structure of human NADPH-cytochrome P450 REDUCTASE(A287P mutant) | x-ray diffraction | A, B | — | — |
| 5FA6 | wild type human CYPOR | x-ray diffraction | A, B | FMN, FAD, NAP | 10 (best 0.85) |
| 5FA6 | Wild type human cypor | x-ray diffraction | A, B | — | — |
| P16435 | AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P16435) | predicted | A | — | 8 (best 0.82) |
Ligands
Experiment against prediction
- 5FA6 chain B against the predicted model P16435: TM-score 1.00, RMSD 0.44 Å
- 5FA6 chain B against the predicted model P16435: TM-score 1.00, RMSD 0.44 Å
- 3QFR chain B against the predicted model P16435: TM-score 1.00, RMSD 0.49 Å
- 3QFR chain B against the predicted model P16435: TM-score 1.00, RMSD 0.49 Å
- 5EMN chain B against the predicted model P16435: TM-score 1.00, RMSD 0.49 Å
- 5EMN chain B against the predicted model P16435: TM-score 1.00, RMSD 0.49 Å
- 1B1C chain A against the predicted model P16435: TM-score 1.00, RMSD 0.31 Å
- 1B1C chain A against the predicted model P16435: TM-score 1.00, RMSD 0.31 Å
- 3QFR chain A against the predicted model P16435: TM-score 0.99, RMSD 0.63 Å
- 3QFR chain A against the predicted model P16435: TM-score 0.99, RMSD 0.63 Å
Elsewhere
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