MolNFT v1 · #260311 · protein
AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P16435)
P16435: “AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P16435)”. 8 pockets (best druggability 0.82). MolNFT v1 #260311 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P16435
- Type
- protein
- Length
- 677 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x58ccFdBDFD832A7AaEbF78524b91376F16D3662e
- Molecule
- NADPH--cytochrome P450 reductase
- UniProt
- P16435
- Pockets
- 8 · best druggability 0.82
Structure
1 distinct chain · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADPH--cytochrome P450 reductase | protein | 677 | 36% helix, 19% strand | P16435 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 554 | 0.82 | 0.88 | 75 | empty |
| 2 | 402 | 0.78 | 0.87 | 65 | empty |
| 3 | 164 | 0.64 | 0.85 | 22 | empty |
| 4 | 145 | 0.53 | 0.80 | 26 | empty |
| 5 | 88 | 0.51 | 0.84 | 23 | empty |
Compared structures
- 5EMN · Crystal structure of human NADPH-cytochrome P450 REDUCTASE(A287P mutant) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 5EMN · Crystal Structure of Human NADPH-Cytochrome P450 Reductase(A287P mutant) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 3QFC · Crystal Structure of Human NADPH-Cytochrome P450 (V492E mutant) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 3QFC · Crystal structure of human NADPH-cytochrome P450 (V492E mutant) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 5FA6 · Wild type human cypor · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 5FA6 · wild type human CYPOR · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 3QE2 · Crystal Structure of Human NADPH-Cytochrome P450 Reductase · an experimental structure of the same protein · chain A against B, TM-score 0.89
- 3QE2 · Crystal structure of human NADPH-cytochrome P450 reductase · an experimental structure of the same protein · chain A against B, TM-score 0.89
- 3QFR · Crystal Structure of Human NADPH-Cytochrome P450 Reductase (R457H Mutant) · an experimental structure of the same protein · chain A against B, TM-score 0.89
- 3QFR · Crystal structure of human NADPH-cytochrome P450 reductase (R457H mutant) · an experimental structure of the same protein · chain A against B, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16435
- Elsewhere: UniProt P16435 · AlphaFold DB P16435
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