UniProt P15144
Aminopeptidase N (P15144)
Aminopeptidase N (UniProt P15144), EC 3.4.11.2: 17 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P15144
- Protein
- Aminopeptidase N
- EC
- 3.4.11.2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 37 · 3 records with a druggable one
Structures
18 records of P15144 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4FYQ | Human aminopeptidase N (CD13) | x-ray diffraction | A | — | — |
| 4FYQ | Human aminopeptidase N (CD13) | x-ray diffraction | A | — | — |
| 4FYR | Human aminopeptidase N (CD13) in complex with bestatin | x-ray diffraction | A | — | — |
| 4FYR | Human aminopeptidase N (CD13) in complex with bestatin | x-ray diffraction | A | — | — |
| 4FYS | Human aminopeptidase N (CD13) in complex with angiotensin IV | x-ray diffraction | A | — | — |
| 4FYS | Human aminopeptidase N (CD13) in complex with angiotensin IV | x-ray diffraction | A | — | — |
| 4FYT | Human aminopeptidase N (CD13) in complex with amastatin | x-ray diffraction | A | — | — |
| 4FYT | Human aminopeptidase N (CD13) in complex with amastatin | x-ray diffraction | A | — | — |
| 5LHD | Structure of glycosylated human aminopeptidase N | x-ray diffraction | A, B, C, D | NAG, BMA, ZN | — |
| 6ATK | Crystal structure of the human coronavirus 229E spike protein receptor binding domain in complex… | x-ray diffraction | A, B, C | NAG, ZN | 19 (best 0.80) |
| 6ATK | Crystal structure of the human coronavirus 229E spike protein receptor binding domain in complex… | x-ray diffraction | A, B, C | NAG, ZN | — |
| 6U7E | Hcov-229E rbd class III in complex with human apn | x-ray diffraction | A, B | NAG, ZN | — |
| 6U7F | HCoV-229E RBD Class IV in complex with human APN | x-ray diffraction | A, B | NAG, ZN | 17 (best 0.80) |
| 6U7F | Hcov-229E rbd class IV in complex with human apn | x-ray diffraction | A, B | NAG, ZN | — |
| 6U7G | Hcov-229E rbd class V in complex with human apn | x-ray diffraction | A, B | NAG, ZN | — |
| 7AEW | 14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and… | x-ray diffraction | CCC, BBB | — | 1 (best 0.53) |
| 7VPQ | Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the… | x-ray diffraction | A, C, E | NAG, ZN | — |
| P15144 | AlphaFold monomer V2.0 prediction for aminopeptidase N (P15144) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6ATK chain B against the predicted model P15144: TM-score 1.00, RMSD 0.65 Å
- 6ATK chain B against the predicted model P15144: TM-score 1.00, RMSD 0.65 Å
- 6ATK chain A against the predicted model P15144: TM-score 1.00, RMSD 0.68 Å
- 6ATK chain A against the predicted model P15144: TM-score 1.00, RMSD 0.68 Å
- 6ATK chain C against the predicted model P15144: TM-score 0.99, RMSD 0.73 Å
- 6ATK chain C against the predicted model P15144: TM-score 0.99, RMSD 0.73 Å
- 6U7F chain A against the predicted model P15144: TM-score 0.99, RMSD 0.78 Å
- 6U7F chain A against the predicted model P15144: TM-score 0.99, RMSD 0.78 Å
- 6U7G chain A against the predicted model P15144: TM-score 0.99, RMSD 0.79 Å
- 4FYQ chain A against the predicted model P15144: TM-score 0.99, RMSD 0.79 Å
Elsewhere
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