MolNFT v1 · #92150 · protein
Human aminopeptidase N (CD13) in complex with angiotensin IV
4FYS: “Human aminopeptidase N (CD13) in complex with angiotensin IV”. X-ray diffraction, 3 ligands (NAG, BMA, SO4), 5 pockets (best druggability 0.83). MolNFT v1 #92150 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4FYS
- Type
- protein
- Length
- 909 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aminopeptidase N; Angiotensin IV
- EC
- 3.4.11.2
- UniProt
- P15144, P01019
- Ligands
- NAG, BMA, SO4
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aminopeptidase N (EC 3.4.11.2) | protein | 903 | 46% helix, 20% strand | P15144 |
| C | Angiotensin IV | protein | 6 | 0% helix, 17% strand | P01019 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A
- BMA · beta-D-mannopyranose · sugar
- SO4 · Sulfate ion · ion · 11 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 944 | 0.83 | 0.84 | 109 | SO4 |
| 2 | 555 | 0.80 | 0.86 | 76 | empty |
| 3 | 402 | 0.65 | 0.79 | 48 | SO4 |
| 4 | 80 | 0.33 | 0.74 | 15 | empty |
| 5 | 51 | 0.29 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–C · 609 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 glycan, 2 disulfide (N-glycosylation, disulfide).
Compared structures
- 4FYS · Human aminopeptidase N (CD13) in complex with angiotensin IV · the same entry in another collection · chain A against A, TM-score 1.00
- P15144 · AlphaFold monomer V2.0 prediction for aminopeptidase N (P15144) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P01019 · AlphaFold monomer V2.0 prediction for angiotensinogen (P01019) · a predicted model of the same protein · chain C against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15144
- Every structure of UniProt P01019
- Elsewhere: RCSB PDB 4FYS · PDBe 4FYS · UniProt P15144 · UniProt P01019
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.