UniProt P15005
5-methylcytosine-specific restriction enzyme B (P15005)
5-methylcytosine-specific restriction enzyme B (UniProt P15005), EC 3.1.21.-: 26 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 69 pockets. Binding sites, druggability and experiment against…
- UniProt
- P15005
- Protein
- 5-methylcytosine-specific restriction enzyme B
- EC
- 3.1.21.-
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 69 · 6 records with a druggable one
Structures
27 records of P15005 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SSC | DNA binding domain of restriction endonuclease bound to DNA | x-ray diffraction | A, B | — | — |
| 3SSC | DNA binding domain of restriction endonuclease bound to DNA | x-ray diffraction | A, B | — | — |
| 3SSD | DNA binding domain of restriction endonuclease bound to DNA | x-ray diffraction | A, B | — | — |
| 3SSD | DNA binding domain of restriction endonuclease bound to DNA | x-ray diffraction | A, B | — | — |
| 3SSE | DNA binding domain of restriction endonuclease bound to DNA | x-ray diffraction | A, B | — | — |
| 3SSE | DNA binding domain of restriction endonuclease bound to DNA | x-ray diffraction | A, B | — | — |
| 6GCD | DNA binding domain of restriction endonuclease McrBC in complex with 5-hydroxymethylcytosine DNA | x-ray diffraction | A, B | — | 3 (best 0.63) |
| 6GCD | DNA binding domain of restriction endonuclease mcrbc in complex with 5-hydroxymethylcytosine DNA | x-ray diffraction | A, B | — | — |
| 6GCE | DNA binding domain of restriction endonuclease mcrbc in complex with 5-formylcytosine DNA | x-ray diffraction | A, B | — | — |
| 6GCF | DNA binding domain of restriction endonuclease McrBC in complex with N4-methylcytosine DNA | x-ray diffraction | A, B | — | 3 (best 0.61) |
| 6GCF | DNA binding domain of restriction endonuclease mcrbc in complex with N4-methylcytosine DNA | x-ray diffraction | A, B | — | — |
| 6HZ4 | Structure of McrBC without DNA binding domains (one half of the full complex) | electron microscopy | A, B, C, D, E, F | GNP, MG, GDP | 20 (best 0.87) |
| 6HZ4 | Structure of mcrbc without DNA binding domains (one half of the full complex) | electron microscopy | A, B, C, D, E, F | GNP, MG, GDP | — |
| 6HZ5 | Structure of McrBC without DNA binding domains (Class 1) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | 20 (best 0.87) |
| 6HZ5 | Structure of mcrbc without DNA binding domains (class 1) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ6 | Structure of mcrbc without DNA binding domains (class 2) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ7 | Structure of McrBC without DNA binding domains (Class 3) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ7 | Structure of mcrbc without DNA binding domains (class 3) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ8 | Structure of McrBC without DNA binding domains (Class 4) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ8 | Structure of mcrbc without DNA binding domains (class 4) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ9 | Structure of McrBC without DNA binding domains (Class 5) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6HZ9 | Structure of mcrbc without DNA binding domains (class 5) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG, GDP | — |
| 6UT6 | Cryo-EM structure of the Escherichia coli McrBC complex | electron microscopy | A, B, C, D, E, F | GDP, GSP, MG | — |
| 6UT6 | Cryo-EM structure of the escherichia COLI mcrbc complex | electron microscopy | A, B, C, D, E, F | GDP, GSP, MG | — |
| 7VSR | Structure of McrBC (stalkless mutant) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | GNP, MG | 20 (best 0.84) |
| 8IJO | Structure of DNA binding domain of McrBC endonuclease bound to DNA: Y41F-L68F double mutant | x-ray diffraction | A, B | — | 3 (best 0.62) |
| P15005 | AlphaFold monomer V2.0 prediction for 5-methylcytosine-specific restriction enzyme B (P15005) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6HZ4 chain C against the predicted model P15005: TM-score 0.99, RMSD 0.66 Å
- 6HZ5 chain I against the predicted model P15005: TM-score 0.99, RMSD 0.68 Å
- 6HZ5 chain C against the predicted model P15005: TM-score 0.99, RMSD 0.68 Å
- 6UT6 chain D against the predicted model P15005: TM-score 0.99, RMSD 0.70 Å
- 6UT6 chain D against the predicted model P15005: TM-score 0.99, RMSD 0.70 Å
- 3SSE chain B against the predicted model P15005: TM-score 0.99, RMSD 0.52 Å
- 3SSE chain B against the predicted model P15005: TM-score 0.99, RMSD 0.52 Å
- 3SSD chain B against the predicted model P15005: TM-score 0.99, RMSD 0.55 Å
- 3SSD chain B against the predicted model P15005: TM-score 0.99, RMSD 0.55 Å
- 6GCF chain B against the predicted model P15005: TM-score 0.98, RMSD 0.58 Å
Elsewhere
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