UniProt P14284
DNA polymerase zeta catalytic subunit (P14284)
DNA polymerase zeta catalytic subunit (UniProt P14284), EC 2.7.7.7: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 165 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P14284
- Protein
- DNA polymerase zeta catalytic subunit
- EC
- 2.7.7.7
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 165 · 10 records with a druggable one
Structures
11 records of P14284 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6V8P | Structure of DNA Polymerase Zeta (Apo) | electron microscopy | A | SF4 | 14 (best 0.85) |
| 6V8P | Structure of DNA polymerase zeta (apo) | electron microscopy | A | SF4 | 14 (best 0.85) |
| 6V93 | Structure of DNA Polymerase Zeta/DNA/dNTP Ternary Complex | electron microscopy | A | SF4, CA, DCP | 19 (best 0.83) |
| 6V93 | Structure of DNA polymerase ZETA/DNA/DNTP ternary complex | electron microscopy | A | SF4, CA, DCP | 19 (best 0.83) |
| 7LXD | Structure of yeast DNA Polymerase Zeta (apo) | electron microscopy | A | SF4 | 17 (best 0.74) |
| 7LXD | Structure of yeast DNA polymerase zeta (apo) | electron microscopy | A | SF4 | 17 (best 0.74) |
| 7S0T | Structure of DNA polymerase zeta with mismatched DNA | electron microscopy | A | SF4, CA, DCP | 17 (best 0.81) |
| 7S0T | Structure of DNA polymerase zeta with mismatched DNA | electron microscopy | A | SF4, CA, DCP | 17 (best 0.81) |
| 8TLQ | Cryo-EM structure of the Rev1-Polzeta-DNA-dCTP complex | electron microscopy | A | CA, DCP, SF4 | 15 (best 0.82) |
| 8TLT | Cryo-EM structure of Rev1(deltaN)-Polzeta-DNA-dCTP complex | electron microscopy | A | SF4, CA, DCP | 16 (best 0.83) |
| P14284 | AlphaFold monomer V2.0 prediction for DNA polymerase zeta catalytic subunit (P14284) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7S0T chain A against the predicted model P14284: TM-score 0.97, RMSD 2.09 Å
- 7S0T chain A against the predicted model P14284: TM-score 0.97, RMSD 2.09 Å
- 8TLT chain A against the predicted model P14284: TM-score 0.96, RMSD 2.19 Å
- 8TLQ chain A against the predicted model P14284: TM-score 0.96, RMSD 2.23 Å
- 6V8P chain A against the predicted model P14284: TM-score 0.96, RMSD 2.25 Å
- 6V8P chain A against the predicted model P14284: TM-score 0.96, RMSD 2.25 Å
- 6V93 chain A against the predicted model P14284: TM-score 0.96, RMSD 2.35 Å
- 6V93 chain A against the predicted model P14284: TM-score 0.96, RMSD 2.35 Å
- 7LXD chain A against the predicted model P14284: TM-score 0.93, RMSD 3.17 Å
- 7LXD chain A against the predicted model P14284: TM-score 0.93, RMSD 3.17 Å
Elsewhere
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