UniProt P11309
Serine/threonine-protein kinase pim-1 (P11309)
Serine/threonine-protein kinase pim-1 (UniProt P11309), EC 2.7.11.1: 298 experimental structures on GenesisL1, 70 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P11309
- Protein
- Serine/threonine-protein kinase pim-1
- EC
- 2.7.11.1
- Experimental structures
- 298
- Predicted models
- 0
- Ligands
- 70
- Pockets
- 19 · 12 records with a druggable one
Structures
298 records of P11309 in the MolNFT archive: 298 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XQZ | Crystal Structure of hPim-1 kinase at 2.1 A resolution | x-ray diffraction | A | — | — |
| 1XQZ | Crystal structure of hpim-1 kinase at 2.1 a resolution | x-ray diffraction | A | — | — |
| 1XR1 | Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution | x-ray diffraction | A | — | — |
| 1XR1 | Crystal structure of hpim-1 kinase in complex with AMP-pnp at 2.1 a resolution | x-ray diffraction | A | — | — |
| 1XWS | Crystal Structure of the human PIM1 kinase domain | x-ray diffraction | A | — | — |
| 1XWS | Crystal structure of the human PIM1 kinase domain | x-ray diffraction | A | — | — |
| 1YHS | Crystal structure of Pim-1 bound to staurosporine | x-ray diffraction | A | — | — |
| 1YHS | Crystal structure of pim-1 bound to staurosporine | x-ray diffraction | A | — | — |
| 1YI3 | Crystal Structure of Pim-1 bound to LY294002 | x-ray diffraction | A | — | — |
| 1YI3 | Crystal structure of pim-1 bound to LY294002 | x-ray diffraction | A | — | — |
| 1YI4 | Structure of Pim-1 bound to adenosine | x-ray diffraction | A | — | — |
| 1YI4 | Structure of pim-1 bound to adenosine | x-ray diffraction | A | — | — |
| 1YWV | Crystal Structures of Proto-Oncogene Kinase Pim1: a Target of Aberrant Somatic Hypermutations in… | x-ray diffraction | A | — | — |
| 1YWV | Crystal structures of proto-oncogene kinase PIM1: a target of aberrant somatic hypermutations in… | x-ray diffraction | A | — | — |
| 1YXS | Crystal Structure of Kinase Pim1 with P123M mutation | x-ray diffraction | A | — | — |
| 1YXS | Crystal structure of kinase PIM1 with P123M mutation | x-ray diffraction | A | — | — |
| 1YXT | Crystal Structure of Kinase Pim1 in complex with AMPPNP | x-ray diffraction | A | — | — |
| 1YXT | Crystal structure of kinase PIM1 in complex with amppnp | x-ray diffraction | A | — | — |
| 1YXU | Crystal Structure of Kinase Pim1 in Complex with AMP | x-ray diffraction | A, B, C, D | — | — |
| 1YXU | Crystal structure of kinase PIM1 in complex with AMP | x-ray diffraction | A, B, C, D | — | — |
| 1YXV | Crystal Structure of Kinase Pim1 in complex with 3,4-Dihydroxy-1-methylquinolin-2(1H)-one | x-ray diffraction | A | — | — |
| 1YXV | Crystal structure of kinase PIM1 in complex with 3,4-dihydroxy-1- methylquinolin-2(1H)-one | x-ray diffraction | A | — | — |
| 1YXX | Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | x-ray diffraction | A | — | — |
| 1YXX | Crystal structure of kinase PIM1 in complex with (3E)-3-[(4- HYDROXYPHENYL)IMINO]-1H-indol-2(3H)-one | x-ray diffraction | A | — | — |
| 2BIK | Human Pim1 phosphorylated on Ser261 | x-ray diffraction | B | — | — |
| 2BIK | Human PIM1 phosphorylated on SER261 | x-ray diffraction | B | — | — |
| 2BIL | The human protein kinase Pim1 in complex with its consensus peptide Pimtide | x-ray diffraction | B | — | — |
| 2BIL | The human protein kinase PIM1 in complex with its consensus peptide pimtide | x-ray diffraction | B | — | — |
| 2BZH | Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU1 | x-ray diffraction | B | — | — |
| 2BZH | Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU1 | x-ray diffraction | B | — | — |
| 2BZI | Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU2 | x-ray diffraction | B | — | — |
| 2BZI | Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU2 | x-ray diffraction | B | — | — |
| 2BZJ | Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU3 | x-ray diffraction | A | — | — |
| 2BZJ | Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU3 | x-ray diffraction | A | — | — |
| 2BZK | Crystal structure of the human PIM1 in complex with amppnp and pimtide | x-ray diffraction | B | — | — |
| 2BZK | Crystal structure of the human PIM1 in complex with amppnp and pimtide | x-ray diffraction | B | — | — |
| 2C3I | Crystal structure of human PIM1 in complex with imidazopyridazin I | x-ray diffraction | B | — | — |
| 2C3I | Crystal structure of human PIM1 in complex with imidazopyridazin I | x-ray diffraction | B | — | — |
| 2J2I | Crystal Structure of the humab PIM1 in complex with LY333531 | x-ray diffraction | B | — | — |
| 2J2I | Crystal structure of the humab PIM1 in complex with LY333531 | x-ray diffraction | B | — | — |
| 2O3P | Crystal structure of Pim1 with Quercetin | x-ray diffraction | A | — | — |
| 2O3P | Crystal structure of PIM1 with quercetin | x-ray diffraction | A | — | — |
| 2O63 | Crystal structure of Pim1 with Myricetin | x-ray diffraction | A | — | — |
| 2O63 | Crystal structure of PIM1 with myricetin | x-ray diffraction | A | — | — |
| 2O64 | Crystal structure of Pim1 with Quercetagetin | x-ray diffraction | A | — | — |
| 2O64 | Crystal structure of PIM1 with quercetagetin | x-ray diffraction | A | — | — |
| 2O65 | Crystal structure of Pim1 with Pentahydroxyflavone | x-ray diffraction | A | — | — |
| 2O65 | Crystal structure of PIM1 with pentahydroxyflavone | x-ray diffraction | A | — | — |
| 2OBJ | Crystal structure of human PIM-1 Kinase in complex with inhibitor | x-ray diffraction | A | — | — |
| 2OBJ | Crystal structure of human pim-1 kinase in complex with inhibitor | x-ray diffraction | A | — | — |
| 2OI4 | Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole | x-ray diffraction | X | — | — |
| 2OI4 | Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole | x-ray diffraction | X | — | — |
| 2XIX | Protein kinase Pim-1 in complex with fragment-1 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XIX | Protein kinase pim-1 in complex with fragment-1 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XIY | Protein kinase Pim-1 in complex with fragment-2 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XIY | Protein kinase pim-1 in complex with fragment-2 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XIZ | Protein kinase Pim-1 in complex with fragment-3 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XIZ | Protein kinase pim-1 in complex with fragment-3 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XJ0 | Protein kinase Pim-1 in complex with fragment-4 from crystallographic fragment screen | x-ray diffraction | A | — | — |
| 2XJ0 | Protein kinase pim-1 in complex with fragment-4 from crystallographic fragment screen | x-ray diffraction | A | — | — |
238 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 10 records
- PO4 · Phosphate ion · in 6 records
- CL · Chloride ion · in 5 records
- 8UB · 3-(2-thiophen-2-ylethenyl)-1~{H}-quinoxalin-2-one · in 3 records
- 3NG · 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid · in 2 records
- 6SD · 3-(4-methoxyphenyl)-1~{H}-pyrazol-5-amine · in 2 records
- 6SN · 5-(3,4-dichlorophenyl)-1~{H}-pyrazol-3-amine · in 2 records
- 6YN · ~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine · in 2 records
- 7LK · 1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile · in 2 records
- 8MK · (~{E})-4-(4-hydroxyphenyl)but-3-en-2-one · in 2 records
- 8MW · 2-cyclopropyl-4,5-dimethyl-thieno[2,3-d]pyrimidine-6-carboxylic acid · in 2 records
- 8N5 · 2,5-dihydro-1~{H}-isothiochromeno[4,3-c]pyrazol-3-one · in 2 records
- 9G5 · (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one · in 2 records
- E2C · 5-(2-chloranylphenoxazin-10-yl)-~{N},~{N}-diethyl-pentan-1-amine · in 2 records
- E2L · 2-chloranyl-10-[3-[(3~{S})-piperidin-3-yl]propyl]phenoxazine · in 2 records
- E2R · 4-[(2-chloranylphenoxazin-10-yl)methyl]cyclohexan-1-amine · in 2 records
- E2U · 2-[4-[2-(7-chloranylpyrido[3,4-b][1,4]benzoxazin-5-yl) ethyl]piperidin-1-yl]ethanamine · in 2 records
- JKW · 2-[(1-methylpiperidin-4-yl)methylamino]-5-[[2-[4-(trifluoromethyloxy)phenyl]-1,3-thiazol-4-yl]methyl]-1,3-thiazol-4-one · in 2 records
- KUY · 5-amino-N-{5-[(4S)-4-aminoazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide · in 2 records
- RTX · 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine · in 2 records
- 06E · 6-[(11-bromanyl-6-oxidanylidene-8-thia-3,5,13-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10, 12-pentaen-4-yl)methylamino]hexanoic acid · in 1 record
- 1RO · (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one · in 1 record
- 5E6 · (1S,3S)-N-{6-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl]pyridin-2-yl}cyclohexane-1,3-diamine · in 1 record
- 5QO · macrocyclic quinoxaline-pyrrolodihydropiperidinone · in 1 record
- 6CD · 2-(tert-butylamino)-3-methyl-8-[(6R)-6-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl]quinazolin-4(3H)-one · in 1 record
- 6ID · ~{N}-[(2~{R})-1-[[(2~{R})-1-[[(2~{R})-1-[[(2~{R})-1-[[(2~{R})-1-[[(2~{R})-1-[[(2~{R})-1-azanyl-5-[[$L^{1}-azanyl($l^{2}-azanylidene)methyl]-$L^{2}-azanyl]-1-oxidanylidene-pentan-2-yl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl · in 1 record
- 6J9 · 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine · in 1 record
- 6S3 · 4-chloranyl-1-methyl-2-[4-(4-methylpiperazin-1-yl) phenyl]pyrrolo[2,3-b]pyridine-6-carboxamide · in 1 record
- 6SF · 2-[3,4-bis(chloranyl)phenoxy]ethanamine · in 1 record
- 6SL · 2-pyridin-3-yl-1~{H}-benzimidazole · in 1 record
Elsewhere
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