UniProt P10845
Botulinum neurotoxin type A (P10845)
Botulinum neurotoxin type A (UniProt P10845), EC 3.4.24.69: 47 experimental structures on GenesisL1, 11 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P10845
- Protein
- Botulinum neurotoxin type A
- EC
- 3.4.24.69
- Experimental structures
- 47
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 19 · 3 records with a druggable one
Structures
47 records of P10845 in the MolNFT archive: 47 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NYY | Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody CR1 | x-ray diffraction | A | — | — |
| 2NYY | Crystal structure of botulinum neurotoxin type a complexed with monoclonal antibody CR1 | x-ray diffraction | A | — | — |
| 2NZ9 | Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2 | x-ray diffraction | A, B | — | — |
| 2NZ9 | Crystal structure of botulinum neurotoxin type a complexed with monoclonal antibody AR2 | x-ray diffraction | A, B | — | — |
| 2VU9 | Crystal structure of botulinum neurotoxin serotype a binding domain in complex with GT1B | x-ray diffraction | A | — | — |
| 2VU9 | Crystal structure of botulinum neurotoxin serotype a binding domain in complex with GT1B | x-ray diffraction | A | — | — |
| 2VUA | Crystal Structure of the Botulinum Neurotoxin Serotype A binding domain | x-ray diffraction | A | — | — |
| 2VUA | Crystal structure of the botulinum neurotoxin serotype a binding domain | x-ray diffraction | A | — | — |
| 3BTA | Crystal structure of botulinum neurotoxin serotype a | x-ray diffraction | A | — | — |
| 3BTA | Crystal structure of botulinum neurotoxin serotype a | x-ray diffraction | A | — | — |
| 3C88 | Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with inhibitory… | x-ray diffraction | A | — | — |
| 3C89 | Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with inhibitory… | x-ray diffraction | A | — | — |
| 3FUO | The Crystal structure of receptor binding domain of botulinum neurotoxin serotype A | x-ray diffraction | A | — | — |
| 3FUO | The crystal structure of receptor binding domain of botulinum neurotoxin serotype a | x-ray diffraction | A | — | — |
| 3ZUR | Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative… | x-ray diffraction | A, B | — | — |
| 3ZUR | Crystal structure of an engineered botulinum neurotoxin type a- SNARE23 derivative… | x-ray diffraction | A, B | — | — |
| 3ZUS | Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative, LC-A-SNAP23-Hn-A | x-ray diffraction | A, B, C, D | — | — |
| 3ZUS | Crystal structure of an engineered botulinum neurotoxin type a- SNARE23 derivative, lc-a-SNAP23-hn-a | x-ray diffraction | A, B, C, D | — | — |
| 4EJ5 | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A wild-type | x-ray diffraction | A | — | — |
| 4EJ5 | Crystal structure of the catalytic domain of botulinum neurotoxin BONT/A wild-type | x-ray diffraction | A | — | — |
| 4EL4 | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S/C165S double mutant | x-ray diffraction | A | — | — |
| 4EL4 | Crystal structure of the catalytic domain of botulinum neurotoxin BONT/A C134S/C165S double mutant | x-ray diffraction | A | — | — |
| 4ELC | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134 mutant with MTSEA… | x-ray diffraction | A | — | — |
| 4ELC | Crystal structure of the catalytic domain of botulinum neurotoxin BONT/A C134 mutant with mtsea… | x-ray diffraction | A | — | — |
| 4HEV | Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate | x-ray diffraction | A, B | — | — |
| 4HEV | Clostridium botulinum serotype a light chain inhibited by adamantane hydroxamate | x-ray diffraction | A, B | — | — |
| 4IQP | Crystal Structure of HCRA-W1266A | x-ray diffraction | A | — | — |
| 4IQP | Crystal structure of hcra-W1266A | x-ray diffraction | A | — | — |
| 4JRA | CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL… | x-ray diffraction | A, B | — | — |
| 4JRA | Crystal structure of the botulinum neurotoxin a receptor-binding domain in complex with the luminal… | x-ray diffraction | A, B | — | — |
| 4ZJX | Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with a Novel Cyclic… | x-ray diffraction | A | — | — |
| 4ZJX | Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with a novel cyclic… | x-ray diffraction | A | — | — |
| 5JLV | Receptor binding domain of botulinum neurotoxin a in complex with human glycosylated SV2C | x-ray diffraction | A, B | — | — |
| 5JMC | Receptor binding domain of botulinum neurotoxin a in complex with rat SV2C | x-ray diffraction | A, C, E, G | — | — |
| 5MK6 | Crystal structure of the receptor-binding domain of botulinum neurotoxin A1 (crystal form 1) | x-ray diffraction | A | NA | — |
| 5MK7 | Crystal structure of the receptor-binding domain of botulinum neurotoxin A1 (crystal form 2) | x-ray diffraction | A | — | 3 (best 0.56) |
| 5MK7 | Crystal structure of the receptor-binding domain of botulinum neurotoxin A1 (crystal form 2) | x-ray diffraction | A | — | — |
| 5TPB | Binding domain of BONT/A complexed with ganglioside variant | x-ray diffraction | A, B | NGA, GAL, SIA | — |
| 5TPC | Binding domain of BONT/A complexed with ganglioside | x-ray diffraction | A | SIA, NGA, GAL | — |
| 5V8P | Small molecule inhibitor abs-143 bound to the botulinum neurotoxin serotype a light chain | x-ray diffraction | A, B | ZN, 90G | — |
| 5V8R | Small Molecule Inhibitor ABS-143 Bound to the Botulinum Neurotoxin Serotype A Light Chain | x-ray diffraction | A, B | ZN, 90J | 10 (best 0.76) |
| 5V8R | Small molecule inhibitor abs-143 bound to the botulinum neurotoxin serotype a light chain | x-ray diffraction | A, B | ZN, 90J | — |
| 5V8U | Small molecule inhibitor abs-143 bound to the botulinum neurotoxin serotype a light chain | x-ray diffraction | A, B | ZN, 90M | — |
| 5VGV | Structure of the C. botulinum neurotoxin serotype A with Cu bound | x-ray diffraction | A | CU | 6 (best 0.71) |
| 5VGV | Structure of the C. botulinum neurotoxin serotype a with cu bound | x-ray diffraction | A | CU | — |
| 5VGX | Structure of the C. botulinum neurotoxin serotype a with hg bound | x-ray diffraction | A | HG | — |
| 6DKK | Structure of bont | x-ray diffraction | A, B | PO4 | — |
Ligands
- ZN · Zinc ion · in 4 records
- 90J · N-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-sulfanylacetamide · in 2 records
- CU · Copper (II) ion · in 2 records
- GAL · beta-D-galactopyranose · in 2 records
- NGA · 2-acetamido-2-deoxy-beta-D-galactopyranose · in 2 records
- SIA · N-acetyl-alpha-neuraminic acid · in 2 records
- 90G · N-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]-2-sulfanylacetamide · in 1 record
- 90M · N-[3-(4-fluorophenyl)-4-methyl-1H-pyrazol-5-yl]-2-sulfanylacetamide · in 1 record
- HG · Mercury (II) ion · in 1 record
- NA · Sodium ion · in 1 record
- PO4 · Phosphate ion · in 1 record
Elsewhere
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