MolNFT v1 · #127017 · protein
Crystal structure of the receptor-binding domain of botulinum neurotoxin A1 (crystal form 2)
5MK7 · Botulinum neurotoxin type a: “Crystal structure of the receptor-binding domain of botulinum neurotoxin A1 (crystal form 2)”. X-ray diffraction, 3 pockets (best druggability 0.56). MolNFT v1 #127017 on GenesisL1: 3D structure…
- PDB
- 5MK7
- Type
- protein
- Length
- 397 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Botulinum neurotoxin type a
- EC
- 3.4.24.69
- UniProt
- P10845
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Botulinum neurotoxin type a (EC 3.4.24.69) | protein | 397 | 7% helix, 47% strand | P10845 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 279 | 0.56 | 0.77 | 29 | empty |
| 2 | 57 | 0.43 | 0.83 | 18 | empty |
| 3 | 95 | 0.42 | 0.78 | 20 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5MK7 · Crystal structure of the receptor-binding domain of botulinum neurotoxin A1 (crystal form… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10845
- Elsewhere: RCSB PDB 5MK7 · PDBe 5MK7 · UniProt P10845
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