UniProt P0CX45
60S ribosomal protein L2-A (P0CX45)
60S ribosomal protein L2-A (UniProt P0CX45): 90 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0CX45
- Protein
- 60S ribosomal protein L2-A
- Experimental structures
- 90
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 57 · 33 records with a druggable one
Structures
91 records of P0CX45 in the MolNFT archive: 90 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J6X | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II) | electron microscopy | L2 | — | — |
| 3J6Y | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I) | electron microscopy | L2 | — | — |
| 3J77 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | L2 | — | — |
| 3J78 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | L2 | — | — |
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | A | — | — |
| 4U3M | Crystal structure of Anisomycin bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U3N | Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U3U | Crystal structure of Cycloheximide bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4N | Crystal structure of Edeine bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4O | Crystal structure of Geneticin bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4Q | Crystal structure of Homoharringtonine bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4R | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4U | Crystal structure of Lycorine bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4Y | Crystal structure of Pactamycin bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U4Z | Crystal structure of Phyllanthoside bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U50 | Crystal structure of Verrucarin bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U51 | Crystal structure of Narciclasine bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U52 | Crystal structure of Nagilactone C bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U53 | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U55 | Crystal structure of Cryptopleurine bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U56 | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4U6F | Crystal structure of T-2 toxin bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | — | — |
| 4V7F | Arx1 pre-60S particle. | electron microscopy | B | — | — |
| 4V7F | ARX1 pre-60S particle. | electron microscopy | B | — | — |
| 4V88 | The structure of the eukaryotic ribosome at 3.0 A resolution. | x-ray diffraction | BA, DA | — | — |
| 4V8T | Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1 | electron microscopy | A | — | — |
| 5FCI | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | x-ray diffraction | L2, l2 | OHX, MG | 1 (best 0.87) |
| 5GAK | Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A | electron microscopy | E | — | 2 (best 0.88) |
| 5H4P | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | electron microscopy | A | — | — |
| 5JCS | Cryo-EM structure of the RIX1-REA1 pre-60S particle | electron microscopy | A | — | 3 (best 0.86) |
| 5JUP | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | F | — | — |
| 5JUS | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | F | — | — |
| 5JUU | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | F | — | 1 (best 0.88) |
| 5M1J | Nonstop ribosomal complex bound with Dom34 and Hbs1 | electron microscopy | A5 | MG | — |
| 5MC6 | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | electron microscopy | AW | — | — |
| 5MEI | Crystal structure of Agelastatin A bound to the 80S ribosome | x-ray diffraction | j, CD | OHX, MG | — |
| 5NDG | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome | x-ray diffraction | L2, l2 | MG | 2 (best 0.89) |
| 5T6R | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | D | MG | 3 (best 0.86) |
| 6GQ1 | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | electron microscopy | A | — | — |
| 6GQB | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | electron microscopy | A | — | — |
| 6GQV | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | electron microscopy | A | — | — |
| 6HD7 | Cryo-EM structure of the ribosome-NatA complex | electron microscopy | E | — | — |
| 6HHQ | Crystal structure of compound C45 bound to the yeast 80S ribosome | x-ray diffraction | j, CD | OHX, MG | — |
| 6I7O | The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways… | electron microscopy | AW, XW | — | — |
| 6M62 | Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta… | electron microscopy | A | — | — |
| 6N8J | Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit | electron microscopy | A | — | 3 (best 0.87) |
| 6N8K | Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit | electron microscopy | A | — | — |
| 6N8L | Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit | electron microscopy | A | — | — |
| 6N8M | Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit | electron microscopy | D | — | — |
| 6N8N | Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit | electron microscopy | D | — | — |
| 6N8O | Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit | electron microscopy | D | — | — |
| 6Q8Y | Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex | electron microscopy | AW | — | — |
| 6QIK | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | B | — | — |
| 6RI5 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | B | — | 1 (best 0.85) |
| 6S05 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | B | — | — |
| 6T7I | Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination. | electron microscopy | LA | — | — |
| 6T83 | Structure of yeast disome (di-ribosome) stalled on poly(A) tract. | electron microscopy | Ay, Da | — | — |
| 6TNU | Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs. | electron microscopy | AW | — | — |
| 6WOO | CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP | electron microscopy | A | — | 1 (best 0.86) |
| 6Z6J | Cryo-EM structure of yeast Lso2 bound to 80S ribosomes under native condition | electron microscopy | LA | — | 2 (best 0.86) |
31 records more on the page itself.
Ligands
Experiment against prediction
- 8EVT chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.48 Å
- 8T2Z chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.59 Å
- 8T2X chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.63 Å
- 8T2Y chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.65 Å
- 8EUB chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.62 Å
- 8EVQ chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.62 Å
- 8AGW chain j against the predicted model P0CX45: TM-score 0.99, RMSD 0.52 Å
- 8AGZ chain j against the predicted model P0CX45: TM-score 0.99, RMSD 0.52 Å
- 7MPJ chain AA against the predicted model P0CX45: TM-score 0.99, RMSD 0.56 Å
- 7ZW0 chain LE against the predicted model P0CX45: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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