UniProt P0CH43
Tau-theraphotoxin-Hs1a (P0CH43)
Tau-theraphotoxin-Hs1a (UniProt P0CH43): 16 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0CH43
- Protein
- Tau-theraphotoxin-Hs1a
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 13 · 5 records with a druggable one
Structures
17 records of P0CH43 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N9Z | Solution structure of K1 lobe of double-knot toxin | solution nmr | A | — | — |
| 2N9Z | Solution structure of K1 lobe of double-knot toxin | solution nmr | A | — | — |
| 2NAJ | Solution structure of K2 lobe of double-knot toxin | solution nmr | A | — | — |
| 2NAJ | Solution structure of K2 lobe of double-knot toxin | solution nmr | A | — | — |
| 5IRX | Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc | electron microscopy | E, F | 6OE, 6O9 | 4 (best 0.70) |
| 5IRX | Structure of TRPV1 in complex with dktx and rtx, determined in lipid nanodisc | electron microscopy | E, F | — | — |
| 6CUC | Solution structure of double knot toxin (DkTx) | solution nmr | A | — | — |
| 6CUC | Solution structure of double knot toxin (dktx) | solution nmr | A | — | — |
| 7L2M | Cryo-EM structure of DkTx/RTX-bound full-length TRPV1 | electron microscopy | E, F | — | 2 (best 0.61) |
| 7L2M | Cryo-EM structure of DKTX/RTX-bound full-length TRPV1 | electron microscopy | E, F | — | — |
| 7L2R | Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state | electron microscopy | F, E | 65I | 4 (best 0.60) |
| 7L2R | Cryo-EM structure of dktx-bound minimal TRPV1 at the pre-open state | electron microscopy | F, E | 65I | — |
| 7L2T | cryo-EM structure of DkTx-bound minimal TRPV1 in partial open state | electron microscopy | F, E | 65I | 2 (best 0.53) |
| 7L2T | Cryo-EM structure of dktx-bound minimal TRPV1 in partial open state | electron microscopy | F, E | 65I | — |
| 7L2U | cryo-EM structure of DkTx-bound minimal TRPV1 in open state | electron microscopy | F, E | XKP | 1 (best 0.54) |
| 7L2U | Cryo-EM structure of dktx-bound minimal TRPV1 in open state | electron microscopy | F, E | XKP | — |
| P0CH43 | AlphaFold monomer V2.0 prediction for tau-theraphotoxin-HS1A (P0CH43) | predicted | A | — | — |
Ligands
- 65I · (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate · in 4 records
- XKP · (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate · in 2 records
- 6O9 · (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate · in 1 record
- 6OE · (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate · in 1 record
Experiment against prediction
- 5IRX chain F against the predicted model P0CH43: TM-score 0.80, RMSD 1.66 Å
- 5IRX chain F against the predicted model P0CH43: TM-score 0.80, RMSD 1.66 Å
- 5IRX chain E against the predicted model P0CH43: TM-score 0.80, RMSD 1.66 Å
- 5IRX chain E against the predicted model P0CH43: TM-score 0.80, RMSD 1.66 Å
- 7L2R chain E against the predicted model P0CH43: TM-score 0.80, RMSD 1.60 Å
- 7L2R chain E against the predicted model P0CH43: TM-score 0.80, RMSD 1.60 Å
- 7L2R chain F against the predicted model P0CH43: TM-score 0.80, RMSD 1.65 Å
- 7L2R chain F against the predicted model P0CH43: TM-score 0.80, RMSD 1.65 Å
- 7L2U chain E against the predicted model P0CH43: TM-score 0.80, RMSD 1.68 Å
- 7L2U chain E against the predicted model P0CH43: TM-score 0.80, RMSD 1.68 Å
Elsewhere
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