UniProt P0C0J0
Streptopain (P0C0J0)
Streptopain (UniProt P0C0J0), EC 3.4.22.10: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0C0J0
- Protein
- Streptopain
- EC
- 3.4.22.10
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 7 · 0 records with a druggable one
Structures
9 records of P0C0J0 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DKI | Crystal structure of the zymogen form of streptococcal pyrogenic exotoxin B active site (C47S)… | x-ray diffraction | A, B, C, D | — | — |
| 1DKI | Crystal structure of the zymogen form of streptococcal pyrogenic exotoxin B active site (C47S)… | x-ray diffraction | A, B, C, D | — | — |
| 1PVJ | Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex | x-ray diffraction | A, B, C, D | — | — |
| 1PVJ | Crystal structure of the streptococcal pyrogenic exotoxin B (speb)- inhibitor complex | x-ray diffraction | A, B, C, D | — | — |
| 6UKD | Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor | x-ray diffraction | A | Q9D, NO3 | — |
| 6UKD | Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor | x-ray diffraction | A | Q9D, NO3 | — |
| 6UQD | Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule… | x-ray diffraction | A, B | QF4 | 3 (best 0.48) |
| 6UQD | Co-complex of S. pyogenes 10782 streptopain bound with a sufex-based optimized small molecule… | x-ray diffraction | A, B | QF4 | — |
| P0C0J0 | AlphaFold monomer V2.0 prediction for streptopain (P0C0J0) | predicted | A | — | 4 (best 0.45) |
Ligands
Experiment against prediction
- 1DKI chain C against the predicted model P0C0J0: TM-score 0.98, RMSD 1.04 Å
- 1DKI chain C against the predicted model P0C0J0: TM-score 0.98, RMSD 1.04 Å
- 1PVJ chain A against the predicted model P0C0J0: TM-score 0.98, RMSD 1.08 Å
- 1PVJ chain A against the predicted model P0C0J0: TM-score 0.98, RMSD 1.08 Å
- 1DKI chain D against the predicted model P0C0J0: TM-score 0.98, RMSD 1.07 Å
- 1DKI chain D against the predicted model P0C0J0: TM-score 0.98, RMSD 1.07 Å
- 1DKI chain B against the predicted model P0C0J0: TM-score 0.98, RMSD 1.09 Å
- 1DKI chain B against the predicted model P0C0J0: TM-score 0.98, RMSD 1.09 Å
- 1DKI chain A against the predicted model P0C0J0: TM-score 0.98, RMSD 1.07 Å
- 1DKI chain A against the predicted model P0C0J0: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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