UniProt P0A7E5
CTP synthase (P0A7E5)
CTP synthase (UniProt P0A7E5), EC 6.3.4.2: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A7E5
- Protein
- CTP synthase
- EC
- 6.3.4.2
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 26 · 3 records with a druggable one
Structures
7 records of P0A7E5 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S1M | Crystal Structure of E. Coli CTP Synthetase | x-ray diffraction | A, B | SO4, MG, IOD | 10 (best 0.75) |
| 1S1M | Crystal structure of E. COLI CTP synthetase | x-ray diffraction | A, B | — | — |
| 2AD5 | Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. coli… | x-ray diffraction | A, B | — | — |
| 2AD5 | Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. COLI… | x-ray diffraction | A, B | — | — |
| 5TKV | X-ray crystal structure of the closed" conformation of CTP-inhibited E. COLI cytidine triphosphate… | x-ray diffraction | A, B | GLN, SO4, MG, CTP | 11 (best 0.74) |
| 5TKV | X-ray crystal structure of the "closed" conformation of CTP-inhibited E. COLI cytidine triphosphate… | x-ray diffraction | A, B | SO4, CTP | — |
| P0A7E5 | AlphaFold monomer V2.0 prediction for CTP synthase (P0A7E5) | predicted | A | — | 5 (best 0.73) |
Ligands
Experiment against prediction
- 5TKV chain A against the predicted model P0A7E5: TM-score 0.97, RMSD 1.03 Å
- 2AD5 chain A against the predicted model P0A7E5: TM-score 0.97, RMSD 1.06 Å
- 2AD5 chain A against the predicted model P0A7E5: TM-score 0.97, RMSD 1.06 Å
- 5TKV chain A against the predicted model P0A7E5: TM-score 0.97, RMSD 1.03 Å
- 1S1M chain A against the predicted model P0A7E5: TM-score 0.97, RMSD 0.97 Å
- 1S1M chain A against the predicted model P0A7E5: TM-score 0.97, RMSD 0.97 Å
- 2AD5 chain B against the predicted model P0A7E5: TM-score 0.97, RMSD 0.93 Å
- 2AD5 chain B against the predicted model P0A7E5: TM-score 0.97, RMSD 0.93 Å
- 1S1M chain B against the predicted model P0A7E5: TM-score 0.97, RMSD 1.02 Å
- 1S1M chain B against the predicted model P0A7E5: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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