UniProt P0A7E3
Orotate phosphoribosyltransferase (P0A7E3)
Orotate phosphoribosyltransferase (UniProt P0A7E3), EC 2.4.2.10: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P0A7E3
- Protein
- Orotate phosphoribosyltransferase
- EC
- 2.4.2.10
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 5 records with a druggable one
Structures
6 records of P0A7E3 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ORO | A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of… | x-ray diffraction | A, B | SO4 | 3 (best 0.71) |
| 1ORO | A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of… | x-ray diffraction | A, B | — | — |
| 6TAI | Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase with an empty active site… | x-ray diffraction | AAA, BBB | — | 5 (best 0.63) |
| 6TAJ | Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase in complex with Orotic acid… | x-ray diffraction | AAA, BBB | ORO | 5 (best 0.69) |
| 6TAK | Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase in complex with Orotic acid… | x-ray diffraction | AAA, BBB | ORO, SO4 | 3 (best 0.75) |
| P0A7E3 | AlphaFold monomer V2.0 prediction for orotate phosphoribosyltransferase (P0A7E3) | predicted | A | — | 1 (best 0.59) |
Ligands
Experiment against prediction
- 1ORO chain B against the predicted model P0A7E3: TM-score 0.99, RMSD 0.49 Å
- 1ORO chain B against the predicted model P0A7E3: TM-score 0.99, RMSD 0.49 Å
- 6TAK chain AAA against the predicted model P0A7E3: TM-score 0.98, RMSD 0.73 Å
- 6TAJ chain BBB against the predicted model P0A7E3: TM-score 0.98, RMSD 0.73 Å
- 1ORO chain A against the predicted model P0A7E3: TM-score 0.98, RMSD 0.76 Å
- 1ORO chain A against the predicted model P0A7E3: TM-score 0.98, RMSD 0.76 Å
- 6TAK chain BBB against the predicted model P0A7E3: TM-score 0.98, RMSD 0.78 Å
- 6TAI chain BBB against the predicted model P0A7E3: TM-score 0.98, RMSD 0.78 Å
- 6TAJ chain AAA against the predicted model P0A7E3: TM-score 0.97, RMSD 0.99 Å
- 6TAI chain AAA against the predicted model P0A7E3: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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