MolNFT v1 · #17377 · protein
A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of escherichia COLI orotate phosphoribosyltransferase
1ORO: “A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of escherichia…”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.71). MolNFT v1 #17377 on GenesisL1: 3D structure…
- PDB
- 1ORO
- Type
- protein
- Length
- 419 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orotate phosphoribosyltransferase
- EC
- 2.4.2.10
- UniProt
- P0A7E3
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Orotate phosphoribosyltransferase (EC 2.4.2.10) | protein | 213 | 45% helix, 23% strand | P0A7E3 |
| B | Orotate phosphoribosyltransferase (EC 2.4.2.10) | protein | 206 | 46% helix, 24% strand | P0A7E3 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 647 | 0.71 | 0.78 | 60 | SO4 |
| 2 | 151 | 0.53 | 0.80 | 31 | empty |
| 3 | 76 | 0.51 | 0.84 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1269 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 1ORO · A flexible loop at the dimer interface is a part of the active site of the adjacent… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A7E3 · AlphaFold monomer V2.0 prediction for orotate phosphoribosyltransferase (P0A7E3) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A7E3
- Elsewhere: RCSB PDB 1ORO · PDBe 1ORO · UniProt P0A7E3
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