UniProt P09733
Tubulin alpha-1 chain (P09733)
Tubulin alpha-1 chain (UniProt P09733): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09733
- Protein
- Tubulin alpha-1 chain
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 82 · 9 records with a druggable one
Structures
14 records of P09733 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4FFB | A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule… | x-ray diffraction | A | MG, GTP | 7 (best 0.78) |
| 4FFB | A TOG:ALPHA/BETA-tubulin complex structure reveals conformation-based mechanisms for a microtubule… | x-ray diffraction | A | — | — |
| 4U3J | TOG2:alpha/beta-tubulin complex | x-ray diffraction | A | MG, GTP | 7 (best 0.79) |
| 4U3J | TOG2:ALPHA/BETA-tubulin complex | x-ray diffraction | A | — | — |
| 5W3F | Yeast tubulin polymerized with GTP in vitro | electron microscopy | A | MG, GTP | 7 (best 0.82) |
| 5W3F | Yeast tubulin polymerized with GTP in vitro | electron microscopy | A | MG, GTP | — |
| 5W3H | Yeast microtubule stabilized with epothilone | electron microscopy | A | GTP, MG | 6 (best 0.82) |
| 5W3H | Yeast microtubule stabilized with epothilone | electron microscopy | A | GTP, MG | — |
| 5W3J | Yeast microtubule stabilized with Taxol assembled from mutated tubulin | electron microscopy | A | GTP, MG | 7 (best 0.83) |
| 5W3J | Yeast microtubule stabilized with taxol assembled from mutated tubulin | electron microscopy | A | GTP, MG | — |
| 8QV0 | Structure of the native microtubule lattice nucleated from the yeast spindle pole body | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N | — | 20 (best 0.84) |
| 8QV2 | Structure of the native y-Tubulin Ring Complex (yTuRC) capping microtubule minus ends at the… | electron microscopy | Ad, Ac, Af, Ae, Ah, Ag, Aj, Ai, Al, Ak, An, Am, Ab, Ap, Ao, Ar, Aq | GTP | 15 (best 0.85) |
| 8QV3 | Structure of the y-Tubulin Small Complex (yTuSC) as part of the native y-Tubulin Ring Complex… | electron microscopy | Ad, Ac | — | 8 (best 0.81) |
| P09733 | AlphaFold monomer V2.0 prediction for tubulin alpha-1 chain (P09733) | predicted | A | — | 5 (best 0.64) |
Ligands
Experiment against prediction
- 4U3J chain A against the predicted model P09733: TM-score 0.98, RMSD 1.08 Å
- 4U3J chain A against the predicted model P09733: TM-score 0.98, RMSD 1.08 Å
- 4FFB chain A against the predicted model P09733: TM-score 0.98, RMSD 1.16 Å
- 4FFB chain A against the predicted model P09733: TM-score 0.98, RMSD 1.16 Å
- 5W3H chain A against the predicted model P09733: TM-score 0.98, RMSD 1.25 Å
- 5W3H chain A against the predicted model P09733: TM-score 0.98, RMSD 1.25 Å
- 5W3F chain A against the predicted model P09733: TM-score 0.97, RMSD 1.35 Å
- 5W3F chain A against the predicted model P09733: TM-score 0.97, RMSD 1.35 Å
- 5W3J chain A against the predicted model P09733: TM-score 0.97, RMSD 1.43 Å
- 5W3J chain A against the predicted model P09733: TM-score 0.97, RMSD 1.43 Å
Elsewhere
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