UniProt P08954
1-phosphatidylinositol phosphodiesterase (P08954)
1-phosphatidylinositol phosphodiesterase (UniProt P08954), EC 4.6.1.13: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08954
- Protein
- 1-phosphatidylinositol phosphodiesterase
- EC
- 4.6.1.13
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
11 records of P08954 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T6M | X-ray Structure of the R70D PI-PLC enzyme: Insight into the role of calcium and surrounding amino… | x-ray diffraction | A, B | CA | 5 (best 0.62) |
| 1T6M | X-ray structure of the R70D pi-plc enzyme: insight into the role of calcium and surrounding amino… | x-ray diffraction | A, B | — | — |
| 2OR2 | Structure of the W47A/W242A Mutant of Bacterial Phosphatidylinositol-Specific Phospholipase C | x-ray diffraction | A, B | — | — |
| 2OR2 | Structure of the W47A/W242A mutant of bacterial phosphatidylinositol- specific phospholipase C | x-ray diffraction | A, B | — | — |
| 3EA1 | Crystal Structure of the Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from… | x-ray diffraction | A, B | — | — |
| 3EA1 | Crystal structure of the Y247S/Y251S mutant of phosphatidylinositol- specific phospholipase C from… | x-ray diffraction | A, B | — | — |
| 3EA2 | Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific… | x-ray diffraction | A, B | — | — |
| 3EA2 | Crystal structure of the myo-inositol bound Y247S/Y251S mutant of phosphatidylinositol-specific… | x-ray diffraction | A, B | — | — |
| 3EA3 | Crystal Structure of the Y246S/Y247S/Y248S/Y251S Mutant of Phosphatidylinositol-Specific… | x-ray diffraction | A, B | — | — |
| 3EA3 | Crystal structure of the Y246S/Y247S/Y248S/Y251S mutant of phosphatidylinositol-specific… | x-ray diffraction | A, B | — | — |
| P08954 | AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol phosphodiesterase (P08954) | predicted | A | — | 1 (best 0.43) |
Ligands
- CA · Calcium ion · in 1 record
Experiment against prediction
- 3EA3 chain A against the predicted model P08954: TM-score 0.99, RMSD 0.62 Å
- 3EA3 chain A against the predicted model P08954: TM-score 0.99, RMSD 0.62 Å
- 3EA1 chain A against the predicted model P08954: TM-score 0.99, RMSD 0.70 Å
- 3EA1 chain A against the predicted model P08954: TM-score 0.99, RMSD 0.70 Å
- 3EA2 chain A against the predicted model P08954: TM-score 0.99, RMSD 0.72 Å
- 3EA2 chain A against the predicted model P08954: TM-score 0.99, RMSD 0.72 Å
- 1T6M chain A against the predicted model P08954: TM-score 0.99, RMSD 0.81 Å
- 1T6M chain A against the predicted model P08954: TM-score 0.99, RMSD 0.81 Å
- 2OR2 chain A against the predicted model P08954: TM-score 0.97, RMSD 1.48 Å
- 2OR2 chain A against the predicted model P08954: TM-score 0.97, RMSD 1.48 Å
Elsewhere
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