MolNFT v1 · #47190 · protein

Structure of the W47A/W242A mutant of bacterial phosphatidylinositol- specific phospholipase C

2OR2 · 1-phosphatidylinositol phosphodiesterase: “Structure of the W47A/W242A mutant of bacterial phosphatidylinositol- specific phospholipase C”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #47190 on GenesisL1: 3D…

PDB: 2OR2
Type: protein
Length: 592 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-phosphatidylinositol phosphodiesterase
EC: 4.6.1.13
UniProt: P08954
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	1-phosphatidylinositol phosphodiesterase (EC 4.6.1.13)	protein	296	32% helix, 21% strand	P08954

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.71	0.97	27	empty
2	177	0.51	0.78	30	empty
3	174	0.50	0.78	30	empty

Interfaces

1 interface between chains.

A–B · 918 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2OR2 · Structure of the W47A/W242A Mutant of Bacterial Phosphatidylinositol-Specific… · the same entry in another collection · chain A against A, TM-score 1.00
P08954 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol phosphodiesterase (P08954) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08954
Elsewhere: RCSB PDB 2OR2 · PDBe 2OR2 · UniProt P08954

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