UniProt P08525
Cytochrome b-c1 complex subunit 8, mitochondrial (P08525)
Cytochrome b-c1 complex subunit 8, mitochondrial (UniProt P08525): 26 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08525
- Protein
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 34 · 6 records with a druggable one
Structures
27 records of P08525 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KB9 | Yeast cytochrome BC1 complex | x-ray diffraction | H | — | — |
| 1KB9 | Yeast cytochrome BC1 complex | x-ray diffraction | H | — | — |
| 1KYO | Yeast cytochrome BC1 complex with bound substrate cytochrome C | x-ray diffraction | H, S | — | — |
| 1KYO | Yeast cytochrome BC1 complex with bound substrate cytochrome C | x-ray diffraction | H, S | — | — |
| 1P84 | HDBT inhibited Yeast Cytochrome bc1 Complex | x-ray diffraction | H | — | — |
| 1P84 | Hdbt inhibited yeast cytochrome BC1 complex | x-ray diffraction | H | — | — |
| 2IBZ | Yeast Cytochrome BC1 Complex with Stigmatellin | x-ray diffraction | G | — | — |
| 2IBZ | Yeast cytochrome BC1 complex with stigmatellin | x-ray diffraction | G | — | — |
| 3CX5 | Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core… | x-ray diffraction | H, S | — | — |
| 3CX5 | Structure of complex III with bound cytochrome C in reduced state and definition of a minimal core… | x-ray diffraction | H, S | — | — |
| 3CXH | Structure of yeast complex III with isoform-2 cytochrome c bound and definition of a minimal core… | x-ray diffraction | H, S | — | — |
| 3CXH | Structure of yeast complex III with isoform-2 cytochrome C bound and definition of a minimal core… | x-ray diffraction | H, S | — | — |
| 4PD4 | Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of… | x-ray diffraction | H | — | — |
| 4PD4 | Structural analysis of atovaquone-inhibited cytochrome BC1 complex reveals the molecular basis of… | x-ray diffraction | H | — | — |
| 6GIQ | Saccharomyces cerevisiae respiratory supercomplex III2IV | electron microscopy | H, S | 8PE, CN3 | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | H, S | PCF, CDL, PEF | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | H, S | PCF, CDL, PEF | — |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | H, S | CDL, PCF, PEF | 6 (best 0.82) |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | H, S | CDL, PCF, PEF | — |
| 6T15 | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | electron microscopy | H, S | PCF, CDL, PEF | 5 (best 0.81) |
| 6T15 | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | electron microscopy | H, S | PCF, CDL, PEF | — |
| 6YMX | CIII2/CIV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | H, S | CN3, PTY, 8PE | 9 (best 0.80) |
| 6YMX | CIII2/CIV respiratory supercomplex from saccharomyces cerevisiae | electron microscopy | H, S | CN3, 8PE | — |
| 8E7S | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | electron microscopy | H, h | CDL, PCF, PEF | 2 (best 0.81) |
| 8EC0 | III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | electron microscopy | H, h | PEF, PGT | 6 (best 0.86) |
| 9ETZ | III2IV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | H, S | PCF, CDL, PEF | 6 (best 0.85) |
| P08525 | AlphaFold monomer V2.0 prediction for cytochrome B-C1 complex subunit 8, mitochondrial (P08525) | predicted | A | — | — |
Ligands
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 9 records
- CDL · Cardiolipin · in 8 records
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · in 8 records
- 8PE · (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate · in 3 records
- CN3 · (2R,5S,11R,14R)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(propanoyloxy)methyl]-4,6,10,12,15-pentaoxa-5,11-diphosphanonadec-1-yl undecanoate · in 3 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
- PTY · Phosphatidylethanolamine · in 1 record
Experiment against prediction
- 6T15 chain H against the predicted model P08525: TM-score 0.85, RMSD 1.53 Å
- 6T15 chain H against the predicted model P08525: TM-score 0.85, RMSD 1.53 Å
- 6HU9 chain H against the predicted model P08525: TM-score 0.85, RMSD 1.51 Å
- 6HU9 chain H against the predicted model P08525: TM-score 0.85, RMSD 1.51 Å
- 6T0B chain H against the predicted model P08525: TM-score 0.84, RMSD 1.56 Å
- 6T0B chain H against the predicted model P08525: TM-score 0.84, RMSD 1.56 Å
- 6GIQ chain H against the predicted model P08525: TM-score 0.84, RMSD 1.57 Å
- 6YMX chain H against the predicted model P08525: TM-score 0.84, RMSD 1.58 Å
- 6YMX chain H against the predicted model P08525: TM-score 0.84, RMSD 1.58 Å
- 4PD4 chain H against the predicted model P08525: TM-score 0.82, RMSD 1.68 Å
Elsewhere
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