UniProt P07896
Peroxisomal bifunctional enzyme (P07896)
Peroxisomal bifunctional enzyme (UniProt P07896), EC 1.1.1.35, 4.2.1.17: 22 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P07896
- Protein
- Peroxisomal bifunctional enzyme
- EC
- 1.1.1.35, 4.2.1.17, 5.3.3.8
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 68 · 6 records with a druggable one
Structures
23 records of P07896 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZCJ | Crystal structure of 3-hydroxyacyl-CoA dehydrogenase | x-ray diffraction | A | — | — |
| 1ZCJ | Crystal structure of 3-hydroxyacyl-CoA dehydrogenase | x-ray diffraction | A | — | — |
| 2X58 | The crystal structure of MFE1 liganded with CoA | x-ray diffraction | A, B | — | — |
| 2X58 | The crystal structure of MFE1 liganded with CoA | x-ray diffraction | A, B | — | — |
| 3ZW8 | Crystal Structure Of Rat Peroxisomal Multifunctional Enzyme Type 1 (rpMFE1) In Apo Form | x-ray diffraction | A, B | — | — |
| 3ZW8 | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) in apo form | x-ray diffraction | A, B | — | — |
| 3ZW9 | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZW9 | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZWA | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZWA | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZWB | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZWB | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZWC | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 3ZWC | Crystal structure of rat peroxisomal multifunctional enzyme type 1 (RPMFE1) complexed with… | x-ray diffraction | A, B | — | — |
| 5MGB | Crystal Structure of Rat Peroxisomal Multifunctional enzyme Type-1 (RPMFE1) Complexed with… | x-ray diffraction | A, B | SO4, CAA, NAD | 15 (best 0.81) |
| 5MGB | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with… | x-ray diffraction | A, B | SO4, CAA, NAD | — |
| 5OMO | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with with… | x-ray diffraction | A, B | SO4, HSC, ZOZ | — |
| 6Z5F | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with… | x-ray diffraction | AAA, BBB | ZOZ, NAD, SO4 | 12 (best 0.81) |
| 6Z5O | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with… | x-ray diffraction | AAA | NAD, SO4, COA, NCA | 5 (best 0.76) |
| 6Z5V | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with… | x-ray diffraction | AAA, BBB | NAD, ZOZ, SO4 | 11 (best 0.80) |
| 6ZIB | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with… | x-ray diffraction | AAA, BBB | CAA, NAI, SO4 | 12 (best 0.78) |
| 6ZIC | Crystal structure of rat peroxisomal multifunctional enzyme type-1 (RPMFE1) complexed with… | x-ray diffraction | AAA, BBB | 3HC, NAI, SO4 | 13 (best 0.78) |
| P07896 | AlphaFold monomer V2.0 prediction for peroxisomal bifunctional enzyme (P07896) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 8 records
- NAD · Nicotinamide-adenine-dinucleotide · in 5 records
- CAA · Acetoacetyl-coenzyme A · in 3 records
- ZOZ · 3-keto-decanoyl-coa · in 3 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 2 records
- 3HC · 3-hydroxybutanoyl-coenzyme A · in 1 record
- COA · Coenzyme A · in 1 record
- HSC · (S)-3-hydroxydecanoyl-coa · in 1 record
- NCA · Nicotinamide · in 1 record
Experiment against prediction
- 1ZCJ chain A against the predicted model P07896: TM-score 0.98, RMSD 1.18 Å
- 1ZCJ chain A against the predicted model P07896: TM-score 0.98, RMSD 1.18 Å
- 3ZW9 chain A against the predicted model P07896: TM-score 0.97, RMSD 1.55 Å
- 3ZW9 chain A against the predicted model P07896: TM-score 0.97, RMSD 1.55 Å
- 2X58 chain A against the predicted model P07896: TM-score 0.97, RMSD 1.58 Å
- 2X58 chain A against the predicted model P07896: TM-score 0.97, RMSD 1.58 Å
- 3ZWA chain A against the predicted model P07896: TM-score 0.96, RMSD 1.63 Å
- 3ZWA chain A against the predicted model P07896: TM-score 0.96, RMSD 1.63 Å
- 3ZW8 chain A against the predicted model P07896: TM-score 0.97, RMSD 1.63 Å
- 3ZW8 chain A against the predicted model P07896: TM-score 0.97, RMSD 1.63 Å
Elsewhere
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