MolNFT v1 · #29565 · protein

Crystal structure of 3-hydroxyacyl-CoA dehydrogenase

1ZCJ · Peroxisomal bifunctional enzyme: “Crystal structure of 3-hydroxyacyl-CoA dehydrogenase”. X-ray diffraction, 2 pockets (best druggability 0.74). MolNFT v1 #29565 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ZCJ
Type: protein
Length: 459 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisomal bifunctional enzyme
EC: 1.1.1.35
UniProt: P07896
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisomal bifunctional enzyme (EC 1.1.1.35)	protein	459	51% helix, 12% strand	P07896

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	942	0.74	0.77	78	empty
2	173	0.50	0.78	36	empty

Compared structures

1ZCJ · Crystal structure of 3-hydroxyacyl-CoA dehydrogenase · the same entry in another collection · chain A against A, TM-score 1.00
P07896 · AlphaFold monomer V2.0 prediction for peroxisomal bifunctional enzyme (P07896) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07896
Elsewhere: RCSB PDB 1ZCJ · PDBe 1ZCJ · UniProt P07896

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