UniProt P07340
Sodium/potassium-transporting ATPase subunit beta-1 (P07340)
Sodium/potassium-transporting ATPase subunit beta-1 (UniProt P07340): 5 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P07340
- Protein
- Sodium/potassium-transporting ATPase subunit beta-1
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 24 · 4 records with a druggable one
Structures
6 records of P07340 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7X22 | Cryo-EM structure of non gastric H,K-ATPase alpha2 K794S in (2K+)E2-AlF state | electron microscopy | B | PCW, NAG, CLR | 5 (best 0.76) |
| 7X23 | Cryo-EM structure of non gastric H,K-ATPase alpha2 SPWC mutant in 3Na+E1-AMPPCPF state | electron microscopy | B | NAG | 5 (best 0.49) |
| 7X24 | Cryo-EM structure of non gastric H,K-ATPase alpha2 SPWC mutant in (2K+)E2-AlF state | electron microscopy | B | PCW, NAG, CLR | 6 (best 0.52) |
| 8IJL | Cyo-EM structure of wildtype non-gastric proton pump in the presence of Na+, AlF and ADP | electron microscopy | B | PCW, NAG, CLR, Q7G | 4 (best 0.53) |
| 8IJM | Cyo-EM structure of K794A non-gastric proton pump in Na+ bound E1AMPPCP state | electron microscopy | B | PCW, CLR, NAG | 4 (best 0.50) |
| P07340 | AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit beta-1 (P07340) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- CLR · Cholesterol · in 4 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 4 records
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · in 1 record
Experiment against prediction
- 8IJL chain B against the predicted model P07340: TM-score 0.97, RMSD 1.11 Å
- 7X22 chain B against the predicted model P07340: TM-score 0.97, RMSD 1.15 Å
- 8IJM chain B against the predicted model P07340: TM-score 0.97, RMSD 1.16 Å
- 7X23 chain B against the predicted model P07340: TM-score 0.96, RMSD 1.23 Å
- 7X24 chain B against the predicted model P07340: TM-score 0.96, RMSD 1.24 Å
Elsewhere
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