UniProt P06869
Urokinase-type plasminogen activator (P06869)
Urokinase-type plasminogen activator (UniProt P06869), EC 3.4.21.73: 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P06869
- Protein
- Urokinase-type plasminogen activator
- EC
- 3.4.21.73
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 4 records with a druggable one
Structures
17 records of P06869 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LAQ | Structure-based engineering of species selectivity in the uPA-uPAR interaction | x-ray diffraction | A, B | — | — |
| 3LAQ | Structure-based engineering of species selectivity in the upa-upar interaction | x-ray diffraction | A, B | — | — |
| 5LHN | The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric… | x-ray diffraction | A | SO4 | 2 (best 0.54) |
| 5LHN | The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric… | x-ray diffraction | A | SO4 | — |
| 5LHP | The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen… | x-ray diffraction | A | SO4, PBZ | — |
| 5LHP | The P-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen… | x-ray diffraction | A | SO4, PBZ | — |
| 5LHQ | The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator… | x-ray diffraction | A | SO4 | — |
| 5LHQ | The egr-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator… | x-ray diffraction | A | SO4 | — |
| 5LHR | The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site… | x-ray diffraction | A | — | 1 (best 0.50) |
| 5LHR | The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site… | x-ray diffraction | A | — | — |
| 5LHS | The ligand free catalytic domain of murine urokinase-type plasminogen activator | x-ray diffraction | B, A, C, D | SO4, NI | — |
| 5LHS | The ligand free catalytic domain of murine urokinase-type plasminogen activator | x-ray diffraction | B, A, C, D | SO4, NI | — |
| 6A8G | The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5 | x-ray diffraction | A, B | PO4 | 3 (best 0.51) |
| 6A8G | The crystal structure of mupain-1-ig in complex with mupa-spd at PH8.5 | x-ray diffraction | A, B | ACE, PO4 | — |
| 6A8N | The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5 | x-ray diffraction | A, B | — | 4 (best 0.49) |
| 6A8N | The crystal structure of mupain-1-ig-2 in complex with mupa-spd at PH8.5 | x-ray diffraction | A, B | — | — |
| P06869 | AlphaFold monomer V2.0 prediction for urokinase-type plasminogen activator (P06869) | predicted | A | — | 5 (best 0.59) |
Ligands
Experiment against prediction
- 5LHR chain A against the predicted model P06869: TM-score 0.98, RMSD 0.93 Å
- 5LHR chain A against the predicted model P06869: TM-score 0.98, RMSD 0.93 Å
- 6A8G chain B against the predicted model P06869: TM-score 0.97, RMSD 1.06 Å
- 6A8G chain B against the predicted model P06869: TM-score 0.97, RMSD 1.06 Å
- 6A8N chain A against the predicted model P06869: TM-score 0.96, RMSD 1.61 Å
- 6A8N chain A against the predicted model P06869: TM-score 0.96, RMSD 1.61 Å
- 6A8G chain A against the predicted model P06869: TM-score 0.96, RMSD 1.63 Å
- 6A8G chain A against the predicted model P06869: TM-score 0.96, RMSD 1.63 Å
- 6A8N chain B against the predicted model P06869: TM-score 0.96, RMSD 1.62 Å
- 5LHN chain A against the predicted model P06869: TM-score 0.96, RMSD 1.52 Å
Elsewhere
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