MolNFT v1 · #492560 · protein
AlphaFold monomer V2.0 prediction for urokinase-type plasminogen activator (P06869)
P06869: “AlphaFold monomer V2.0 prediction for urokinase-type plasminogen activator (P06869)”. 5 pockets (best druggability 0.59). MolNFT v1 #492560 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P06869
- Type
- protein
- Length
- 433 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7FDF8b382C6a36A8772D1A265E8e480c7DF0A9C1
- Molecule
- Urokinase-type plasminogen activator
- UniProt
- P06869
- Pockets
- 5 · best druggability 0.59
Structure
1 distinct chain · 8% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Urokinase-type plasminogen activator | protein | 433 | 8% helix, 30% strand | P06869 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 479 | 0.59 | 0.74 | 47 | empty |
| 2 | 97 | 0.52 | 0.83 | 20 | empty |
| 3 | 146 | 0.47 | 0.77 | 21 | empty |
| 4 | 111 | 0.41 | 0.76 | 19 | empty |
| 5 | 59 | 0.27 | 0.73 | 18 | empty |
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 5LHR · The catalytic domain of murine urokinase-type plasminogen activator in complex with the… · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 5LHR · The catalytic domain of murine urokinase-type plasminogen activator in complex with the… · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 6A8G · The crystal structure of mupain-1-ig in complex with mupa-spd at PH8.5 · an experimental structure of the same protein · chain A against B, TM-score 0.55
- 6A8G · The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5 · an experimental structure of the same protein · chain A against B, TM-score 0.55
- 5LHQ · The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen… · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 5LHQ · The egr-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen… · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 5LHP · The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type… · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 5LHP · The P-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type… · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 6A8N · The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5 · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 6A8N · The crystal structure of mupain-1-ig-2 in complex with mupa-spd at PH8.5 · an experimental structure of the same protein · chain A against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06869
- Elsewhere: UniProt P06869 · AlphaFold DB P06869
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