UniProt P06804
Tumor necrosis factor (P06804)
Tumor necrosis factor (UniProt P06804): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P06804
- Protein
- Tumor necrosis factor
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 12 · 1 record with a druggable one
Structures
7 records of P06804 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2TNF | 1.4 a resolution structure of mouse tumor necrosis factor, towards modulation of its selectivity… | x-ray diffraction | A, B, C | — | — |
| 2TNF | 1.4 a resolution structure of mouse tumor necrosis factor, towards modulation of its selectivity… | x-ray diffraction | A, B, C | — | — |
| 7KP7 | asymmetric mTNF-alpha hTNFR1 complex | x-ray diffraction | B, A, C | SO4, NAG | 12 (best 0.75) |
| 7KP7 | Asymmetric mtnf-alpha HTNFR1 complex | x-ray diffraction | B, A, C | SO4, NAG | — |
| 7KP8 | asymmetric mTNF-alpha hTNFR1 complex | x-ray diffraction | A, B, C | A7G | — |
| 7KP8 | Asymmetric mtnf-alpha HTNFR1 complex | x-ray diffraction | A, B, C | A7G | — |
| P06804 | AlphaFold monomer V2.0 prediction for tumor necrosis factor (P06804) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7KP7 chain B against the predicted model P06804: TM-score 0.99, RMSD 0.42 Å
- 7KP7 chain B against the predicted model P06804: TM-score 0.99, RMSD 0.42 Å
- 2TNF chain A against the predicted model P06804: TM-score 0.99, RMSD 0.53 Å
- 2TNF chain A against the predicted model P06804: TM-score 0.99, RMSD 0.53 Å
- 7KP8 chain B against the predicted model P06804: TM-score 0.98, RMSD 0.62 Å
- 7KP8 chain B against the predicted model P06804: TM-score 0.98, RMSD 0.62 Å
- 7KP8 chain C against the predicted model P06804: TM-score 0.97, RMSD 0.93 Å
- 7KP8 chain C against the predicted model P06804: TM-score 0.97, RMSD 0.93 Å
- 7KP8 chain A against the predicted model P06804: TM-score 0.96, RMSD 0.89 Å
- 7KP8 chain A against the predicted model P06804: TM-score 0.96, RMSD 0.89 Å
Elsewhere
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