UniProt P05214

Detyrosinated tubulin alpha-3 chain (P05214)

Detyrosinated tubulin alpha-3 chain (UniProt P05214), EC 3.6.5.-: 3 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: P05214
Protein: Detyrosinated tubulin alpha-3 chain
EC: 3.6.5.-
Experimental structures: 3
Predicted models: 1
Ligands: 3
Pockets: 60 · 4 records with a druggable one

Structures

4 records of P05214 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8I7O	In situ structure of axonemal doublet microtubules in mouse sperm with 16-nm repeat	electron microscopy	AE, AG, AI, BE, BG, BI, CG, CI, DE, DG, EE, EG, FE, FG, GE, GG, GI, HE, HG, HI, IE, IG, II, JE, JG, KE, KG, KI, LE, LG, LI, ME, MG, MI, NE, NG, NI, OE, OG, OI, PE, PG, PI, QE, QG, QI, RE, RG, RI, SE, SG, SI, TG, TI, UE, UG, VE, VG, WE, WG, WI	GTP	19 (best 0.90)
8I7R	In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat	electron microscopy	AC, AE, AG, AI, AK, AM, BC, BE, BG, BI, BK, BM, CC, CE, CG, CI, CK, CM, DA, DC, DE, DG, DI, DK, EA, EC, EE, EG, EI, EK, FA, FC, FE, FG, FI, FK, GA, GC, GE, GG, GI, GK, HA, HC, HE, HG, HI, HK, IA, IC, IE, IG, II, IK, IM, JA, JC, JE, JG, JI, JK, KA, KC, KE, KG, KI, KK, LA, LC, LE, LG, LI, LK, MC, ME, MG, MI, MK, MM, NA, NC, NE, NG, NI, NK, OA, OC, OE, OG, OI, OK, PA, PC, PE, PG, PI, PK, PM, QC, QE, QG, QI, QK, QM, RC, RE, RG, RI, RK, RM, SC, SE, SG, SI, SK, SM, TC, TE, TG, TI, TK, TM, UA, UC, UE, UG, UI, UK, VA, VC, VE, VG, VI, VK, WA, WC, WE, WG, WI, WK	GTP	20 (best 0.90)
8IYJ	Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm	electron microscopy	AA, AC, AE, AG, AI, AK, AM, AO, BC, BE, BG, BI, BK, BM, BO, CC, CE, CG, CI, CK, CM, CO, CQ, DC, DE, DG, DI, DK, DM, DO, DQ, EA, EC, EE, EG, EI, EK, EM, EO, FA, FC, FE, FG, FI, FK, FM, FO, GA, GC, GE, GG, GI, GK, GM, GO, HA, HC, HE, HG, HI, HK, HM, HO, IA, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, JO, JQ, KA, KC, KE, KG, KI, KK, KM, KO, LA, LC, LE, LG, LI, LK, LM, LO, MA, MC, ME, MG, MI, MK, MM, MO, NA, NC, NE, NG, NI, NK, NM, NO, OA, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SA, SC, SE, SG, SI, SK, SM, TA, TC, TE, TG, TI, TK, TM, UA, UC, UE, UG, UI, UK, UM, UO, VA, VC, VE, VG, VI, VK, VM, VO, WA, WC, WE, WG, WI, WK, WM, WO	GTP, MG, GDP	18 (best 0.89)
P05214	AlphaFold monomer V2.0 prediction for tubulin alpha-3 chain (P05214)	predicted	A	—	3 (best 0.58)

Ligands

GTP · Guanosine-5'-triphosphate · in 3 records
GDP · Guanosine-5'-diphosphate · in 1 record
MG · Magnesium ion · in 1 record

Experiment against prediction

8IYJ chain DK against the predicted model P05214: TM-score 0.99, RMSD 0.88 Å
8IYJ chain DO against the predicted model P05214: TM-score 0.99, RMSD 0.92 Å
8IYJ chain KC against the predicted model P05214: TM-score 0.99, RMSD 0.93 Å
8IYJ chain DE against the predicted model P05214: TM-score 0.99, RMSD 0.92 Å
8IYJ chain QM against the predicted model P05214: TM-score 0.98, RMSD 0.93 Å
8IYJ chain BC against the predicted model P05214: TM-score 0.98, RMSD 0.94 Å
8IYJ chain QI against the predicted model P05214: TM-score 0.98, RMSD 0.94 Å
8IYJ chain DM against the predicted model P05214: TM-score 0.98, RMSD 0.94 Å
8IYJ chain JO against the predicted model P05214: TM-score 0.98, RMSD 0.95 Å
8IYJ chain PO against the predicted model P05214: TM-score 0.98, RMSD 0.95 Å

Elsewhere

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.