UniProt P05050
Alpha-ketoglutarate-dependent dioxygenase AlkB (P05050)
Alpha-ketoglutarate-dependent dioxygenase AlkB (UniProt P05050), EC 1.14.11.33: 73 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 2 pockets. Binding sites, druggability and experiment against…
- UniProt
- P05050
- Protein
- Alpha-ketoglutarate-dependent dioxygenase AlkB
- EC
- 1.14.11.33
- Experimental structures
- 73
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 2 · 2 records with a druggable one
Structures
74 records of P05050 in the MolNFT archive: 73 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FD8 | Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FD8 | Crystal structure of alkb in complex with FE(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDF | Crystal Structure of AlkB in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDF | Crystal structure of alkb in complex with CO(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDG | Crystal Structure of AlkB in complex with Fe(II), succinate, and methylated trinucleotide T-meA-T | x-ray diffraction | A | — | — |
| 2FDG | Crystal structure of alkb in complex with FE(II), succinate, and methylated trinucleotide T-mea-T | x-ray diffraction | A | — | — |
| 2FDH | Crystal Structure of AlkB in complex with Mn(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDH | Crystal structure of alkb in complex with MN(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDI | Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDI | Crystal structure of alkb in complex with FE(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDJ | Crystal Structure of AlkB in complex with Fe(II) and succinate | x-ray diffraction | A | — | — |
| 2FDJ | Crystal structure of alkb in complex with FE(II) and succinate | x-ray diffraction | A | — | — |
| 2FDK | Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 2FDK | Crystal structure of alkb in complex with FE(II), 2-oxoglutarate, and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3BI3 | X-ray structure of AlkB protein bound to dsDNA containing 1meA/A with cofactors | x-ray diffraction | A | — | — |
| 3BI3 | X-ray structure of alkb protein bound to dsdna containing 1MEA/A with cofactors | x-ray diffraction | A | — | — |
| 3BIE | X-ray structure of E coli AlkB bound to dsDNA containing 1meA/T with Mn and 2KG | x-ray diffraction | A | — | — |
| 3BIE | X-ray structure of E COLI alkb bound to dsdna containing 1MEA/T with mn and 2KG | x-ray diffraction | A | — | — |
| 3BKZ | X-ray structure of E coli AlkB crosslinked to dsDNA in the active site | x-ray diffraction | A | — | — |
| 3BKZ | X-ray structure of E COLI alkb crosslinked to dsdna in the active site | x-ray diffraction | A | — | — |
| 3I2O | Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3I2O | Crystal structure of alkb in complex with FE(II), 2-oxoglutarate and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3I3M | Crystal Structure of AlkB in complex with Mn(II), 2-oxoglutarate and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3I3M | Crystal structure of alkb in complex with MN(II), 2-oxoglutarate and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3I3Q | Crystal Structure of AlkB in complex with Mn(II) and 2-oxoglutarate | x-ray diffraction | A, B | — | — |
| 3I3Q | Crystal structure of alkb in complex with MN(II) and 2-oxoglutarate | x-ray diffraction | A, B | — | — |
| 3I49 | Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3I49 | Crystal structure of alkb in complex with FE(II), 2-oxoglutarate and methylated trinucleotide… | x-ray diffraction | A | — | — |
| 3KHB | Crystal structure of Escherichia coli AlkB with Co(II) and 2-OG | x-ray diffraction | A, B | — | — |
| 3KHB | Crystal structure of escherichia COLI alkb with CO(II) and 2-og | x-ray diffraction | A, B | — | — |
| 3KHC | Crystal Structure of Escherichia coli AlkB in complex with ssDNA containing a 1-methylguanine lesion | x-ray diffraction | A, B | — | — |
| 3KHC | Crystal structure of escherichia COLI alkb in complex with ssdna containing a 1-methylguanine lesion | x-ray diffraction | A, B | — | — |
| 3O1M | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1M | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1O | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1O | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1P | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1P | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1R | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1R | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1S | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1S | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1T | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1T | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1U | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1U | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3O1V | Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase | x-ray diffraction | A | — | — |
| 3O1V | Iron-catalyzed oxidation intermediates captured in a DNA repair dioxygenase | x-ray diffraction | A | — | — |
| 3T3Y | Crystal structure of AlkB in complex with Fe(III) and 2-(3-hydroxypicolinomido)acetic acid | x-ray diffraction | A | — | — |
| 3T3Y | Crystal structure of alkb in complex with FE(III) and 2-(3- HYDROXYPICOLINOMIDO)ACETIC acid | x-ray diffraction | A | — | — |
| 3T4H | Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine | x-ray diffraction | B | — | — |
| 3T4H | Crystal structure of alkb in complex with FE(III) and N-oxalyl-S-(3- nitrobenzyl)-L-cysteine | x-ray diffraction | B | — | — |
| 3T4V | Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(2-napthalenemethyl)-L-cysteine | x-ray diffraction | A | — | — |
| 3T4V | Crystal structure of alkb in complex with FE(III) and N-oxalyl-S-(2- napthalenemethyl)-L-cysteine | x-ray diffraction | A | — | — |
| 4JHT | Crystal Structure of AlkB in complex with 5-carboxy-8-hydroxyquinoline (IOX1) | x-ray diffraction | A | — | — |
| 4JHT | Crystal structure of alkb in complex with 5-carboxy-8-hydroxyquinoline (IOX1) | x-ray diffraction | A | — | — |
| 4NID | Crystal structure of AlkB protein with cofactors bound to dsDNA containing m6A | x-ray diffraction | A | — | — |
| 4NID | Crystal structure of alkb protein with cofactors bound to dsdna containing M6A | x-ray diffraction | A | — | — |
| 4NIG | Crystal structure of AlkB D135I/E136H mutant protein with cofactors bound to dsDNA containing m6A/A | x-ray diffraction | A | — | — |
| 4NIG | Crystal structure of alkb D135I/E136H mutant protein with cofactors bound to dsdna containing M6A/A | x-ray diffraction | A | — | — |
14 records more on the page itself.
Ligands
- AKG · 2-oxoglutaric acid · in 4 records
- FE · Fe (III) ion · in 4 records
- MN · Manganese (II) ion · in 2 records
- O5W · [(3~{S},5~{R})-5-(6-azanyl-1-methyl-purin-9-yl)-2-(phosphonooxymethyl)oxolan-3-yl] [(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl hydrogen phosphate · in 2 records
- UPW · 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid · in 2 records
Experiment against prediction
- 3BI3 chain A against the predicted model P05050: TM-score 1.00, RMSD 0.26 Å
- 3BI3 chain A against the predicted model P05050: TM-score 1.00, RMSD 0.26 Å
- 4ZHN chain A against the predicted model P05050: TM-score 1.00, RMSD 0.26 Å
- 2FDF chain A against the predicted model P05050: TM-score 1.00, RMSD 0.26 Å
- 2FDF chain A against the predicted model P05050: TM-score 1.00, RMSD 0.26 Å
- 3BKZ chain A against the predicted model P05050: TM-score 1.00, RMSD 0.28 Å
- 3BKZ chain A against the predicted model P05050: TM-score 1.00, RMSD 0.28 Å
- 3I3M chain A against the predicted model P05050: TM-score 1.00, RMSD 0.29 Å
- 3I3M chain A against the predicted model P05050: TM-score 1.00, RMSD 0.29 Å
- 3O1M chain A against the predicted model P05050: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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