UniProt P05026
Sodium/potassium-transporting ATPase subunit beta-1 (P05026)
Sodium/potassium-transporting ATPase subunit beta-1 (UniProt P05026): 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P05026
- Protein
- Sodium/potassium-transporting ATPase subunit beta-1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 36 · 6 records with a druggable one
Structures
11 records of P05026 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7E1Z | Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state | electron microscopy | B | NAG, Y01, PC1 | — |
| 7E1Z | Cryo EM structure of a na+-bound NA+,K+-ATPase in the E1 state | electron microscopy | B | NAG, Y01, PC1 | — |
| 7E20 | Cryo EM structure of a K+-bound NA+,K+-ATPase in the E2 state | electron microscopy | B | NAG, Y01, PC1 | — |
| 7E21 | Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state with ATP-gamma-S | electron microscopy | B | NAG, Y01, PC1 | 7 (best 0.76) |
| 7E21 | Cryo EM structure of a na+-bound NA+,K+-ATPase in the E1 state with ATP-gamma-S | electron microscopy | B | NAG, Y01, PC1 | — |
| 8D3U | Human alpha3 Na+/K+-ATPase in its Na+-occluded state | electron microscopy | B | — | 5 (best 0.72) |
| 8D3V | Human alpha3 Na+/K+-ATPase in its cytoplasmic side-open state | electron microscopy | B | — | 7 (best 0.70) |
| 8D3W | Human alpha3 Na+/K+-ATPase in its AMPPCP-bound cytoplasmic side-open state | electron microscopy | B | — | 9 (best 0.70) |
| 8D3X | Human alpha3 Na+/K+-ATPase in its K+-occluded state | electron microscopy | B | — | 3 (best 0.79) |
| 8ZYJ | Cryo-EM structure of human testis-specific Na+,K+-ATPase alpha4 in ouabain-bound form | electron microscopy | B | Q7G, PCW, NAG | 5 (best 0.78) |
| P05026 | AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit beta-1 (P05026) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 5 records
- Y01 · Cholesterol hemisuccinate · in 5 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 1 record
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · in 1 record
Experiment against prediction
- 8ZYJ chain B against the predicted model P05026: TM-score 0.98, RMSD 1.12 Å
- 7E20 chain B against the predicted model P05026: TM-score 0.97, RMSD 1.17 Å
- 8D3U chain B against the predicted model P05026: TM-score 0.97, RMSD 1.18 Å
- 7E1Z chain B against the predicted model P05026: TM-score 0.97, RMSD 1.25 Å
- 7E1Z chain B against the predicted model P05026: TM-score 0.97, RMSD 1.25 Å
- 7E21 chain B against the predicted model P05026: TM-score 0.97, RMSD 1.30 Å
- 7E21 chain B against the predicted model P05026: TM-score 0.97, RMSD 1.30 Å
- 8D3W chain B against the predicted model P05026: TM-score 0.95, RMSD 1.75 Å
- 8D3V chain B against the predicted model P05026: TM-score 0.95, RMSD 1.77 Å
- 8D3X chain B against the predicted model P05026: TM-score 0.94, RMSD 1.87 Å
Elsewhere
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