UniProt P04629
High affinity nerve growth factor receptor (P04629)
High affinity nerve growth factor receptor (UniProt P04629), EC 2.7.10.1: 90 experimental structures on GenesisL1, 45 ligands bound, 14 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P04629
- Protein
- High affinity nerve growth factor receptor
- EC
- 2.7.10.1
- Experimental structures
- 90
- Predicted models
- 0
- Ligands
- 45
- Pockets
- 14 · 9 records with a druggable one
Structures
90 records of P04629 in the MolNFT archive: 90 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HE7 | Human Nerve growth factor receptor TrkA | x-ray diffraction | A | — | — |
| 1HE7 | Human nerve growth factor receptor trka | x-ray diffraction | A | — | — |
| 1SHC | Shc ptb domain complexed with a trka receptor phosphopeptide, NMR, minimized average structure | solution nmr | B | — | — |
| 1SHC | Shc ptb domain complexed with a trka receptor phosphopeptide, NMR, minimized average structure | solution nmr | B | — | — |
| 1WWA | Ngf binding domain of human trka receptor | x-ray diffraction | X, Y | — | — |
| 1WWA | Ngf binding domain of human trka receptor | x-ray diffraction | X, Y | — | — |
| 1WWW | Ngf in complex with domain 5 of the trka receptor | x-ray diffraction | X, Y | — | — |
| 1WWW | Ngf in complex with domain 5 of the trka receptor | x-ray diffraction | X, Y | — | — |
| 2IFG | Structure of the extracellular segment of human TRKA in complex with nerve growth factor | x-ray diffraction | A, B | — | — |
| 2IFG | Structure of the extracellular segment of human trka in complex with nerve growth factor | x-ray diffraction | A, B | — | — |
| 2N90 | TrkA transmembrane domain NMR structure in DPC micelles | solution nmr | A, B | — | — |
| 2N90 | Trka transmembrane domain NMR structure in dpc micelles | solution nmr | A, B | — | — |
| 4AOJ | Human TrkA in complex with the inhibitor AZ-23 | x-ray diffraction | A, B, C | — | — |
| 4AOJ | Human trka in complex with the inhibitor az-23 | x-ray diffraction | A, B, C | — | — |
| 4CRP | Solution structure of a TrkAIg2 domain construct for use in drug discovery | solution nmr | A | — | — |
| 4CRP | Solution structure of a TRKAIG2 domain construct for use in drug discovery | solution nmr | A | — | — |
| 4F0I | Crystal structure of apo TrkA | x-ray diffraction | A, B | — | — |
| 4F0I | Crystal structure of apo trka | x-ray diffraction | A, B | — | — |
| 4GT5 | Crystal structure of the inactive TrkA kinase domain | x-ray diffraction | A | — | — |
| 4GT5 | Crystal structure of the inactive trka kinase domain | x-ray diffraction | A | — | — |
| 4PMM | The structure of TrkA kinase bound to the inhibitor… | x-ray diffraction | A | — | — |
| 4PMM | The structure of trka kinase bound to the inhibitor N-(3-cyclopropyl… | x-ray diffraction | A | — | — |
| 4PMP | The structure of TrkA kinase bound to the inhibitor… | x-ray diffraction | A | — | — |
| 4PMP | The structure of trka kinase bound to the inhibitor 1-cyclopropyl-1… | x-ray diffraction | A | — | — |
| 4PMS | The structure of TrkA kinase bound to the inhibitor… | x-ray diffraction | A | — | — |
| 4PMS | The structure of trka kinase bound to the inhibitor 4-naphthalen-1-yl… | x-ray diffraction | A | — | — |
| 4PMT | The structure of TrkA kinase bound to the inhibitor… | x-ray diffraction | A | — | — |
| 4PMT | The structure of trka kinase bound to the inhibitor N~4~-(4-morpholin… | x-ray diffraction | A | — | — |
| 4YNE | (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK… | x-ray diffraction | A | — | — |
| 4YNE | (R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk… | x-ray diffraction | A | — | — |
| 4YPS | (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK… | x-ray diffraction | A | — | — |
| 4YPS | (R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk… | x-ray diffraction | A | — | — |
| 5H3Q | Crystal structure of trka kinase with ligand | x-ray diffraction | A | — | — |
| 5I8A | TrkA with (6~{R})-3-methylsulfanyl-6-phenyl-1-(1~{H}-pyrazol-3-yl)-6,7-dihydro-5~{H}-thieno[3,4-c]py… | x-ray diffraction | A | 69C, CL | — |
| 5I8A | Trka with (6~{R})-3-methylsulfanyl-6-phenyl-1-(1~{H}-pyrazol-3-yl)-6… | x-ray diffraction | A | — | — |
| 5JFS | Crystal structure of TrkA in complex with PF-00593174 | x-ray diffraction | A | 6K0 | 1 (best 0.75) |
| 5JFS | Crystal structure of trka in complex with pf-00593174 | x-ray diffraction | A | — | — |
| 5JFV | Crystal structure of TrkA in complex with PF-05206283 | x-ray diffraction | A | 6K1 | 1 (best 0.74) |
| 5JFV | Crystal structure of trka in complex with pf-05206283 | x-ray diffraction | A | — | — |
| 5JFW | Crystal structure of TrkA in complex with PF-05247452 | x-ray diffraction | A | 6K2 | — |
| 5JFW | Crystal structure of trka in complex with pf-05247452 | x-ray diffraction | A | — | — |
| 5JFX | Crystal structure of TrkA in complex with PF-06273340 | x-ray diffraction | A | 6K4 | — |
| 5JFX | Crystal structure of trka in complex with pf-06273340 | x-ray diffraction | A | — | — |
| 5KMI | TrkA JM-kinase with 1-(9{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea | x-ray diffraction | A | 6UE | — |
| 5KMI | Trka jm-kinase with 1-(9{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl- pyrimidin-5-YL)UREA | x-ray diffraction | A | 6UE | — |
| 5KMJ | TrkA JM-kinase with {N}-(2-pyridylmethyl)-2-[2-(2-thienyl)indol-1-yl]acetamide | x-ray diffraction | A | 6UF | 2 (best 0.76) |
| 5KMJ | Trka jm-kinase with {N}-(2-pyridylmethyl)-2-[2-(2-THIENYL)INDOL-1- YL]ACETAMIDE | x-ray diffraction | A | 6UF | — |
| 5KMK | Trka jm-kinase with 2-fluoro-{N}-[2-(4-fluorophenyl)-6-methyl-3… | x-ray diffraction | A | 6UG | — |
| 5KML | Trka jm-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2- (TRIFLUOROMETHYL)PHENYL]METHYL]UREA | x-ray diffraction | A | ACE, 6UH | — |
| 5KMM | TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1-naphthyl)urea | x-ray diffraction | A | 6UJ | — |
| 5KMM | Trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1- NAPHTHYL)UREA | x-ray diffraction | A | 6UJ | — |
| 5KMN | Trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2- (TRIFLUOROMETHYL)PHENYL]METHYL]UREA | x-ray diffraction | A | ACE, 6UK | — |
| 5KMO | TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea | x-ray diffraction | A | 6UM | — |
| 5KMO | Trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2- PYRIDYL)UREA | x-ray diffraction | A | 6UM | — |
| 5KVT | The structure of trka kinase domain bound to the inhibitor entrectinib | x-ray diffraction | A | YMX | — |
| 5KVT | The structure of trka kinase domain bound to the inhibitor entrectinib | x-ray diffraction | A | YMX | — |
| 5WR7 | Crystal structure of trk-a complexed with a selective inhibitor CH7057288 | x-ray diffraction | A | RCH | — |
| 6D1Y | Crystal structure of Tyrosine-protein kinase receptor in complex with… | x-ray diffraction | A | FQJ | — |
| 6D1Y | Crystal structure of tyrosine-protein kinase receptor in complex with… | x-ray diffraction | A | FQJ | — |
| 6D1Z | Crystal structure of tyrosine-protein kinase receptor in complex with… | x-ray diffraction | A | FQD, FQM | — |
30 records more on the page itself.
Ligands
- 22L · 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one · in 2 records
- 6UE · 1-(9~{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea · in 2 records
- 6UF · ~{N}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide · in 2 records
- 6UJ · 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-naphthalen-1-yl-urea · in 2 records
- 6UM · 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-pyridin-2-yl-urea · in 2 records
- ACE · Acetyl group · in 2 records
- B9C · N-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide · in 2 records
- CL · Chloride ion · in 2 records
- FKY · 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy) phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide · in 2 records
- FQD · 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one · in 2 records
- FQJ · 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl) benzamide · in 2 records
- L0M · N-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-2-(10H-phenoxazin-10-yl)acetamide · in 2 records
- L0P · N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- OOJ · N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl) methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea · in 2 records
- OQS · N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[1-(4-methoxyphenyl)-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl]acetamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- YMX · Entrectinib · in 2 records
- 69C · (6R)-3-(methylsulfanyl)-6-phenyl-1-(1H-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5H)-one · in 1 record
- 6K0 · N-{4-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-N'-(2,4-difluorophenyl)urea · in 1 record
- 6K1 · N-{5-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide · in 1 record
- 6K2 · 2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide · in 1 record
- 6K4 · N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide · in 1 record
- 6UG · 2-fluoranyl-~{N}-[2-(4-fluorophenyl)-6-methyl-pyridin-3-yl]-4-(trifluoromethyl)benzamide · in 1 record
- 6UH · 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea · in 1 record
- 6UK · 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea · in 1 record
- A4U · N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide · in 1 record
- A6X · 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide · in 1 record
- AQ6 · 4-[[4-azanyl-3-(4-cyclohexylpiperazin-1-yl)-9,10-bis(oxidanylidene)anthracen-1-yl]amino]benzoic acid · in 1 record
- CVY · 4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]-~{N}-[3-(1-methylpyrazol-4-yl)-1~{H}-indazol-5-yl]-2-(trifluoromethyl)benzamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.