UniProt P04390
Type II restriction enzyme EcoRV (P04390)
Type II restriction enzyme EcoRV (UniProt P04390), EC 3.1.21.4: 64 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 327 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P04390
- Protein
- Type II restriction enzyme EcoRV
- EC
- 3.1.21.4
- Experimental structures
- 64
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 327 · 64 records with a druggable one
Structures
65 records of P04390 in the MolNFT archive: 64 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AZ0 | Ecorv ENDONUCLEASE/DNA complex | x-ray diffraction | A, B | CA | 6 (best 0.85) |
| 1AZ0 | Ecorv ENDONUCLEASE/DNA complex | x-ray diffraction | A, B | CA | 6 (best 0.85) |
| 1AZ3 | Ecorv endonuclease, unliganded, form B | x-ray diffraction | A, B | — | 6 (best 0.57) |
| 1AZ3 | Ecorv endonuclease, unliganded, form B | x-ray diffraction | A, B | — | 6 (best 0.57) |
| 1AZ4 | Ecorv endonuclease, unliganded, form B, T93A mutant | x-ray diffraction | A, B | — | 8 (best 0.52) |
| 1AZ4 | Ecorv endonuclease, unliganded, form B, T93A mutant | x-ray diffraction | A, B | — | 8 (best 0.52) |
| 1B94 | Restriction endonuclease ecorv with calcium | x-ray diffraction | A, B | CA | 6 (best 0.85) |
| 1B94 | Restriction endonuclease ecorv with calcium | x-ray diffraction | A, B | CA | 6 (best 0.85) |
| 1B95 | Analysis of a mutational hot-spot in the ecorv restriction endonuclease: a catalytic role for a… | x-ray diffraction | A, B | — | 5 (best 0.86) |
| 1B95 | Analysis of a mutational hot-spot in the ecorv restriction endonuclease: a catalytic role for a… | x-ray diffraction | A, B | — | 5 (best 0.86) |
| 1B96 | Analysis of a mutational hot-spot in the ecorv restriction endonuclease: a catalytic role for a… | x-ray diffraction | A, B | — | 6 (best 0.85) |
| 1B96 | Analysis of a mutational hot-spot in the ecorv restriction endonuclease: a catalytic role for a… | x-ray diffraction | A, B | — | 6 (best 0.85) |
| 1B97 | Analysis of a mutational hot-spot in the ecorv restriction endonuclease: a catalytic role for a… | x-ray diffraction | A, B | — | 4 (best 0.85) |
| 1B97 | Analysis of a mutational hot-spot in the ecorv restriction endonuclease: a catalytic role for a… | x-ray diffraction | A, B | — | 4 (best 0.85) |
| 1BGB | Ecorv endonuclease complex with 5'-cgggatatccc DNA | x-ray diffraction | A, B | — | 3 (best 0.84) |
| 1BGB | Ecorv endonuclease complex with 5'-cgggatatccc DNA | x-ray diffraction | A, B | — | 3 (best 0.84) |
| 1BSS | Ecorv-T93A/DNA/CA2+ | x-ray diffraction | A, B | CA | 5 (best 0.85) |
| 1BSS | Ecorv-T93A/DNA/CA2+ | x-ray diffraction | A, B | CA | 5 (best 0.85) |
| 1BSU | Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction… | x-ray diffraction | A, B | CA | 6 (best 0.83) |
| 1BSU | Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction… | x-ray diffraction | A, B | CA | 6 (best 0.83) |
| 1BUA | Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction… | x-ray diffraction | A, B | — | 6 (best 0.86) |
| 1BUA | Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction… | x-ray diffraction | A, B | — | 6 (best 0.86) |
| 1EO3 | Inhibition of ecorv endonuclease by deoxyribo-3'-S-phosphorothiolates: a high resolution X-ray… | x-ray diffraction | A, B | MG | 5 (best 0.84) |
| 1EO3 | Inhibition of ecorv endonuclease by deoxyribo-3'-S-phosphorothiolates: a high resolution X-ray… | x-ray diffraction | A, B | MG | 5 (best 0.84) |
| 1EO4 | Ecorv bound to MN2+ and cognate DNA containing a 3'S substition at the cleavage site | x-ray diffraction | A, B | MN | 2 (best 0.84) |
| 1EO4 | Ecorv bound to MN2+ and cognate DNA containing a 3'S substition at the cleavage site | x-ray diffraction | A, B | MN | 2 (best 0.84) |
| 1EON | Ecorv bound to 3'-S-phosphorothiolate DNA and CA2+ | x-ray diffraction | A, B | CL | 6 (best 0.83) |
| 1EON | Ecorv bound to 3'-S-phosphorothiolate DNA and CA2+ | x-ray diffraction | A, B | CL | 6 (best 0.83) |
| 1EOO | Ecorv bound to cognate DNA | x-ray diffraction | A, B | — | 2 (best 0.84) |
| 1EOO | Ecorv bound to cognate DNA | x-ray diffraction | A, B | — | 2 (best 0.84) |
| 1EOP | Ecorv bound to cognate DNA | x-ray diffraction | A, B | — | 7 (best 0.84) |
| 1EOP | Ecorv bound to cognate DNA | x-ray diffraction | A, B | — | 7 (best 0.84) |
| 1RV5 | Complex of ecorv endonuclease with D(AAAGAT)/D(ATCTT) | x-ray diffraction | A, B | — | 5 (best 0.82) |
| 1RV5 | Complex of ecorv endonuclease with D(AAAGAT)/D(ATCTT) | x-ray diffraction | A, B | — | 5 (best 0.82) |
| 1RVA | MG2+ binding to the active site of eco rv endonuclease: a crystallographic study of complexes with… | x-ray diffraction | A, B | — | 7 (best 0.85) |
| 1RVA | MG2+ binding to the active site of eco rv endonuclease: a crystallographic study of complexes with… | x-ray diffraction | A, B | — | 7 (best 0.85) |
| 1RVB | MG2+ binding to the active site of eco rv endonuclease: a crystallographic study of complexes with… | x-ray diffraction | A, B | MG | 6 (best 0.83) |
| 1RVB | MG2+ binding to the active site of eco rv endonuclease: a crystallographic study of complexes with… | x-ray diffraction | A, B | MG | 6 (best 0.83) |
| 1RVC | MG2+ binding to the active site of eco rv endonuclease: a crystallographic study of complexes with… | x-ray diffraction | A, B | MG | 8 (best 0.75) |
| 1RVC | MG2+ binding to the active site of eco rv endonuclease: a crystallographic study of complexes with… | x-ray diffraction | A, B | MG | 8 (best 0.75) |
| 1RVE | The crystal structure of ecorv endonuclease and of its complexes with cognate and non-cognate DNA… | x-ray diffraction | A, B | — | 4 (best 0.71) |
| 1RVE | The crystal structure of ecorv endonuclease and of its complexes with cognate and non-cognate DNA… | x-ray diffraction | A, B | — | 4 (best 0.71) |
| 1STX | Structure of the K38A mutant of EcoRV bound to cognate DNA and Mn2+ | x-ray diffraction | A, B | MN | 4 (best 0.84) |
| 1STX | Structure of the K38A mutant of ecorv bound to cognate DNA and MN2+ | x-ray diffraction | A, B | MN | 4 (best 0.84) |
| 1SUZ | The structure of K92A EcoRV bound to cognate DNA and Mg2+ | x-ray diffraction | A, B | MG, NA | 3 (best 0.82) |
| 1SUZ | The structure of K92A ecorv bound to cognate DNA and MG2+ | x-ray diffraction | A, B | MG, NA | 3 (best 0.82) |
| 1SX5 | K38A EcoRV bound to cleaved DNA and Mn2+: P1 crystal form | x-ray diffraction | A, B | MN | 4 (best 0.80) |
| 1SX5 | K38A ecorv bound to cleaved DNA and MN2+: P1 crystal form | x-ray diffraction | A, B | MN | 4 (best 0.80) |
| 1SX8 | EcoRV bound to cognate DNA and Mn2+ | x-ray diffraction | A, B | MN | 2 (best 0.80) |
| 1SX8 | Ecorv bound to cognate DNA and MN2+ | x-ray diffraction | A, B | MN | 2 (best 0.80) |
| 2B0D | EcoRV Restriction Endonuclease/GAATTC/Ca2+ | x-ray diffraction | A, B | CA | 3 (best 0.83) |
| 2B0D | Ecorv restriction ENDONUCLEASE/GAATTC/CA2+ | x-ray diffraction | A, B | CA | 3 (best 0.83) |
| 2B0E | EcoRV Restriction Endonuclease/GAAUTC/Ca2+ | x-ray diffraction | A, B | CA | 6 (best 0.84) |
| 2B0E | Ecorv restriction ENDONUCLEASE/GAAUTC/CA2+ | x-ray diffraction | A, B | CA | 6 (best 0.84) |
| 2GE5 | EcoRV Restriction Endonuclease C-terminal deletion mutant/GATATC/Ca2+ | x-ray diffraction | A, B | CA | 5 (best 0.86) |
| 2GE5 | Ecorv restriction endonuclease C-terminal deletion MUTANT/GATATC/CA2+ | x-ray diffraction | A, B | CA | 5 (best 0.86) |
| 2RVE | The crystal structure of ecorv endonuclease and of its complexes with cognate and non-cognate DNA… | x-ray diffraction | A, B | — | 3 (best 0.86) |
| 2RVE | The crystal structure of ecorv endonuclease and of its complexes with cognate and non-cognate DNA… | x-ray diffraction | A, B | — | 3 (best 0.86) |
| 4RVE | The crystal structure of ecorv endonuclease and of its complexes with cognate and non-cognate DNA… | x-ray diffraction | A, B, C | — | 7 (best 0.81) |
| 4RVE | The crystal structure of ecorv endonuclease and of its complexes with cognate and non-cognate DNA… | x-ray diffraction | A, B, C | — | 7 (best 0.81) |
5 records more on the page itself.
Ligands
Experiment against prediction
- 1B96 chain A against the predicted model P04390: TM-score 1.00, RMSD 0.22 Å
- 1B96 chain A against the predicted model P04390: TM-score 1.00, RMSD 0.22 Å
- 1SX5 chain A against the predicted model P04390: TM-score 1.00, RMSD 0.24 Å
- 1SX5 chain A against the predicted model P04390: TM-score 1.00, RMSD 0.24 Å
- 1STX chain A against the predicted model P04390: TM-score 1.00, RMSD 0.30 Å
- 1STX chain A against the predicted model P04390: TM-score 1.00, RMSD 0.30 Å
- 1B97 chain A against the predicted model P04390: TM-score 1.00, RMSD 0.31 Å
- 1B97 chain A against the predicted model P04390: TM-score 1.00, RMSD 0.31 Å
- 1BUA chain A against the predicted model P04390: TM-score 1.00, RMSD 0.30 Å
- 1BUA chain A against the predicted model P04390: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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