UniProt P02786
Transferrin receptor protein 1 (P02786)
Transferrin receptor protein 1 (UniProt P02786): 36 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 89 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02786
- Protein
- Transferrin receptor protein 1
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 89 · 6 records with a druggable one
Structures
37 records of P02786 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CX8 | Crystal structure of the ectodomain of human transferrin receptor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1CX8 | Crystal structure of the ectodomain of human transferrin receptor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1DE4 | Hemochromatosis protein hfe complexed with transferrin receptor | x-ray diffraction | C, F, I | — | — |
| 1DE4 | Hemochromatosis protein hfe complexed with transferrin receptor | x-ray diffraction | C, F, I | — | — |
| 1SUV | Structure of Human Transferrin Receptor-Transferrin Complex | electron microscopy | A, B | — | — |
| 1SUV | Structure of human transferrin receptor-transferrin complex | electron microscopy | A, B | — | — |
| 2NSU | Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM… | electron microscopy | A, B | — | — |
| 2NSU | Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM… | electron microscopy | A, B | — | — |
| 3KAS | Machupo virus GP1 bound to human transferrin receptor 1 | x-ray diffraction | A | — | — |
| 3KAS | Machupo virus GP1 bound to human transferrin receptor 1 | x-ray diffraction | A | — | — |
| 3S9L | Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 2 | x-ray diffraction | A, B | — | — |
| 3S9L | Complex between transferrin receptor 1 and transferrin with iron in the N-lobe, cryocooled 2 | x-ray diffraction | A, B | — | — |
| 3S9M | Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 1 | x-ray diffraction | A, B | — | — |
| 3S9M | Complex between transferrin receptor 1 and transferrin with iron in the N-lobe, cryocooled 1 | x-ray diffraction | A, B | — | — |
| 3S9N | Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, room temperature | x-ray diffraction | A, B | — | — |
| 3S9N | Complex between transferrin receptor 1 and transferrin with iron in the N-lobe, room temperature | x-ray diffraction | A, B | — | — |
| 6D03 | Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human… | electron microscopy | A, B | NAG, CA | 12 (best 0.87) |
| 6D03 | Cryo-EM structure of a plasmodium vivax invasion complex essential for entry into human… | electron microscopy | A, B | NAG, CA | — |
| 6D04 | Cryo-EM structure of a plasmodium vivax invasion complex essential for entry into human… | electron microscopy | A, B | NAG, CA | — |
| 6D05 | Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human… | electron microscopy | A, B | NAG, CA | — |
| 6D05 | Cryo-EM structure of a plasmodium vivax invasion complex essential for entry into human… | electron microscopy | A, B | NAG, CA | — |
| 6GSR | Single Particle Cryo-EM map of human Transferrin receptor 1 - H-Ferritin complex at 5.5 Angstrom… | electron microscopy | Ab, Aq | — | — |
| 6H5I | Single Particle Cryo-EM map of human Transferrin receptor 1 - H-Ferritin complex. | electron microscopy | Ab, Aq | — | — |
| 6OKD | Crystal Structure of human transferrin receptor in complex with a cystine-dense peptide | x-ray diffraction | A, B | NAG | 12 (best 0.80) |
| 6OKD | Crystal structure of human transferrin receptor in complex with a cystine-dense peptide | x-ray diffraction | A, B | NAG | — |
| 6W3H | Brain delivery of therapeutic proteins using an Fc fragment blood- brain barrier transport vehicle… | x-ray diffraction | C, D | — | — |
| 6WRV | Crystal structure of computationally designed protein 3DS18 in complex with the human Transferrin… | x-ray diffraction | A, B, E | NAG, BMA, CA | 20 (best 0.85) |
| 6WRV | Crystal structure of computationally designed protein 3DS18 in complex with the human transferrin… | x-ray diffraction | A, B, E | NAG, CA | — |
| 6WRW | Crystal structure of computationally designed protein 2DS25.5 in complex with the human Transferrin… | x-ray diffraction | A, B | NAG, CA | 18 (best 0.84) |
| 6WRW | Crystal structure of computationally designed protein 2DS25.5 in complex with the human transferrin… | x-ray diffraction | A, B | NAG, CA | — |
| 6WRX | Crystal structure of computationally designed protein 2DS25.1 in complex with the human Transferrin… | x-ray diffraction | A, B | NAG, CA | 17 (best 0.84) |
| 6WRX | Crystal structure of computationally designed protein 2DS25.1 in complex with the human transferrin… | x-ray diffraction | A, B | NAG, CA | — |
| 6Y76 | AP01 - a redesigned transferrin receptor apical domain | x-ray diffraction | A, B | NA | 1 (best 0.48) |
| 6Y76 | AP01 - a redesigned transferrin receptor apical domain | x-ray diffraction | A, B | NA | — |
| 7ZQS | Cryo-EM structure of human transferrin receptor 1 bound to DNA aptamer | electron microscopy | B, D | NAG | — |
| 8P0Z | AP01-S2.3 - a variant of a redesigned transferrin receptor apical domain | x-ray diffraction | A | NA, BO3 | — |
| P02786 | AlphaFold monomer V2.0 prediction for transferrin receptor protein 1 (P02786) | predicted | A | — | 9 (best 0.78) |
Ligands
Experiment against prediction
- 7ZQS chain B against the predicted model P02786: TM-score 0.99, RMSD 0.95 Å
- 3S9L chain A against the predicted model P02786: TM-score 0.99, RMSD 1.00 Å
- 3S9L chain A against the predicted model P02786: TM-score 0.99, RMSD 1.00 Å
- 3S9N chain A against the predicted model P02786: TM-score 0.99, RMSD 1.00 Å
- 3S9N chain A against the predicted model P02786: TM-score 0.99, RMSD 1.00 Å
- 3S9M chain A against the predicted model P02786: TM-score 0.99, RMSD 1.03 Å
- 3S9M chain A against the predicted model P02786: TM-score 0.99, RMSD 1.03 Å
- 3S9L chain B against the predicted model P02786: TM-score 0.99, RMSD 1.04 Å
- 3S9L chain B against the predicted model P02786: TM-score 0.99, RMSD 1.04 Å
- 1DE4 chain C against the predicted model P02786: TM-score 0.99, RMSD 1.10 Å
Elsewhere
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