UniProt P02718
Acetylcholine receptor subunit delta (P02718)
Acetylcholine receptor subunit delta (UniProt P02718): 24 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 123 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02718
- Protein
- Acetylcholine receptor subunit delta
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 123 · 13 records with a druggable one
Structures
25 records of P02718 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EQ8 | Three-dimensional structure of the pentameric helical bundle of the acetylcholine receptor M2… | solid-state nmr | A, B, C, D, E | — | — |
| 1EQ8 | Three-dimensional structure of the pentameric helical bundle of the acetylcholine receptor M2… | solid-state nmr | A, B, C, D, E | — | — |
| 6UWZ | Cryo-EM structure of torpedo acetylcholine receptor in complex with alpha-bungarotoxin | electron microscopy | B | NAG, POV | — |
| 7QKO | Torpedo muscle-type nicotinic acetylcholine receptor - resting conformation | electron microscopy | C | NAG, MAN, POV | — |
| 7QL5 | Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | electron microscopy | C | NAG, POV, NCT | — |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | C | NAG, MAN, CCE | 9 (best 0.83) |
| 7QL6 | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | electron microscopy | C | NAG, CCE | — |
| 7SMM | Cryo-EM structure of Torpedo acetylcholine receptor in apo form | electron microscopy | B | NAG, POV | 11 (best 0.80) |
| 7SMM | Cryo-EM structure of torpedo acetylcholine receptor in apo form | electron microscopy | B | NAG, POV | — |
| 7SMQ | Cryo-EM structure of Torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | B | NAG, POV, CLR | 11 (best 0.79) |
| 7SMQ | Cryo-EM structure of torpedo acetylcholine receptor in apo form with added cholesterol | electron microscopy | B | NAG, POV, CLR | — |
| 7SMR | Cryo-EM structure of Torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | B | NAG, CCE, POV | 9 (best 0.84) |
| 7SMR | Cryo-EM structure of torpedo acetylcholine receptor in complex with carbachol, desensitized state | electron microscopy | B | NAG, CCE, POV | — |
| 7SMS | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine | electron microscopy | B | NAG, TC9, POV | 9 (best 0.83) |
| 7SMS | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine | electron microscopy | B | NAG, TC9, POV | — |
| 7SMT | Cryo-EM structure of Torpedo acetylcholine receptor in complex with d-tubocurarine and carbachol | electron microscopy | B | NAG, CCE, POV | 9 (best 0.83) |
| 7SMT | Cryo-EM structure of torpedo acetylcholine receptor in complex with D- tubocurarine and carbachol | electron microscopy | B | NAG, CCE, POV | — |
| 7Z14 | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | C | NAG | 10 (best 0.72) |
| 7Z14 | Cryo-EM structure of torpedo nicotinic acetylcholine receptor in complex with a short-chain… | electron microscopy | C | NAG | 10 (best 0.72) |
| 8ESK | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium… | electron microscopy | B | NAG, RBR, POV | 10 (best 0.81) |
| 8F2S | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium… | electron microscopy | B | NAG, RBR, POV | 9 (best 0.86) |
| 8F6Y | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate… | electron microscopy | B | NAG, CHT, POV | 8 (best 0.82) |
| 8F6Z | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine… | electron microscopy | B | NAG, MAN, SCK, POV | 9 (best 0.84) |
| 8QQM | nicotinic acetylcholine receptor in intact synaptic membrane | electron microscopy | B | — | 9 (best 0.87) |
| P02718 | AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit delta (P02718) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 21 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 17 records
- CCE · 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium · in 6 records
- MAN · alpha-D-mannopyranose · in 3 records
- CLR · Cholesterol · in 2 records
- RBR · rocuronium · in 2 records
- TC9 · D-tubocurarine · in 2 records
- CHT · Choline ion · in 1 record
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 1 record
- SCK · 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(n,n,n-trimethylethanaminium) · in 1 record
Experiment against prediction
- 7Z14 chain C against the predicted model P02718: TM-score 0.98, RMSD 0.88 Å
- 7Z14 chain C against the predicted model P02718: TM-score 0.98, RMSD 0.88 Å
- 7QKO chain C against the predicted model P02718: TM-score 0.98, RMSD 0.94 Å
- 7QL5 chain C against the predicted model P02718: TM-score 0.98, RMSD 0.98 Å
- 7SMM chain B against the predicted model P02718: TM-score 0.98, RMSD 0.97 Å
- 7SMM chain B against the predicted model P02718: TM-score 0.98, RMSD 0.97 Å
- 7SMT chain B against the predicted model P02718: TM-score 0.98, RMSD 0.97 Å
- 7SMT chain B against the predicted model P02718: TM-score 0.98, RMSD 0.97 Å
- 7SMQ chain B against the predicted model P02718: TM-score 0.98, RMSD 0.97 Å
- 7SMQ chain B against the predicted model P02718: TM-score 0.98, RMSD 0.97 Å
Elsewhere
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